PMID- 31910112
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20210531
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Linking)
VI  - 30
IP  - 4
DP  - 2020 Apr
TI  - Development of Gestational Age-Specific Thyroid Function Test Reference Intervals 
      in Four Analytic Platforms Through Multilevel Modeling.
PG  - 598-608
LID - 10.1089/thy.2019.0323 [doi]
AB  - Background: A population-based reference interval (RI) of thyroid hormones in 
      pregnancy using a standardized methodology is crucial for clinicians to make 
      accurate diagnoses and important for the comparison of test results obtained from 
      different analytic platforms. Methods: We enrolled 600 healthy Chinese women to 
      obtain longitudinal serum samples across gestation, after exclusion of subjects 
      with antibodies to thyroid peroxidase, thyroglobulin or thyrotropin receptor. 
      Gestational age-specific RIs were constructed by using polynomial regression 
      equations with MLwiN. Results: Free thyroxine (fT4) levels rose to a peak at the 
      7th-8th gestational weeks and then declined gradually till 28th week, while 
      thyrotropin (TSH) level decreased from early pregnancy to a nadir at the 9th 
      week. The data support the recent notion by the American Thyroid Association to 
      raise the TSH upper RI to 4.0 mIU/L. We also demonstrate that thyroid hormone 
      reference ranges are not affected in a mildly iodine-deficient population and by 
      including women with the presence of antibodies against thyroid peroxidase and 
      thyroglobulin who are otherwise healthy. Conclusions: The study highlights a 
      methodology in constructing gestational age-specific thyroid function test RIs on 
      different analytic platforms to provide a better interpretation and comparison of 
      results obtained across different platforms.
FAU - Yuen, Lai Yuk
AU  - Yuen LY
AD  - Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, 
      New Territories, Hong Kong.
FAU - Chan, Michael Ho Ming
AU  - Chan MHM
AD  - Department of Chemical Pathology, The Chinese University of Hong Kong, New 
      Territories, Hong Kong.
FAU - Sahota, Daljit Singh
AU  - Sahota DS
AD  - Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, 
      New Territories, Hong Kong.
FAU - Lit, Lydia Choi Wan
AU  - Lit LCW
AD  - Department of Chemical Pathology, The Chinese University of Hong Kong, New 
      Territories, Hong Kong.
FAU - Ho, Chung Shun
AU  - Ho CS
AD  - Department of Chemical Pathology, The Chinese University of Hong Kong, New 
      Territories, Hong Kong.
FAU - Ma, Ronald Ching Wan
AU  - Ma RCW
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, New 
      Territories, Hong Kong.
AD  - Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, 
      New Territories, Hong Kong.
AD  - Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, 
      New Territories, Hong Kong.
FAU - Tam, Wing Hung
AU  - Tam WH
AD  - Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, 
      New Territories, Hong Kong.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200221
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications/blood/*diagnosis/physiopathology
MH  - Reference Values
MH  - Thyroid Diseases/blood/*diagnosis/physiopathology
MH  - Thyroid Function Tests
MH  - Thyroid Gland/*physiology
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
OTO - NOTNLM
OT  - immunoassay
OT  - multilevel modeling
OT  - pregnancy
OT  - reference interval
OT  - thyroid function test
EDAT- 2020/01/08 06:00
MHDA- 2021/06/01 06:00
CRDT- 2020/01/08 06:00
PHST- 2020/01/08 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
PHST- 2020/01/08 06:00 [entrez]
AID - 10.1089/thy.2019.0323 [doi]
PST - ppublish
SO  - Thyroid. 2020 Apr;30(4):598-608. doi: 10.1089/thy.2019.0323. Epub 2020 Feb 21.