PMID- 31910912
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20210106
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 123
IP  - 8
DP  - 2020 Apr 28
TI  - Dietary intake of phloridzin from natural occurrence in foods.
PG  - 942-950
LID - 10.1017/S0007114520000033 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is one of the major diseases of our times. 
      Besides being a considerable inconvenience for the patient, the associated 
      healthcare expenses are tremendous. One of the cornerstones of T2DM prevention is 
      a healthy diet, including a variety of fruits and vegetables. Apples are touted 
      to have health benefits, and the apple polyphenol, phloridzin, has gained 
      interest in recent years as it can reduce intestinal sugar uptake by inhibition 
      of the Na/glucose cotransporter 1. By researching the amount of phloridzin in 
      different food sources and linking them to their consumption data, we could 
      estimate the average and high-level phloridzin consumption in Europe. On average, 
      European people consume 0.7-7.5 mg/d phloridzin, the main contributors being 
      apples and apple juice. High-level consumers may get up to 52 mg/d of phloridzin. 
      Older people are more at risk of developing T2DM, yet they consume less 
      phloridzin than adolescents and adults, as determined by our survey. Management 
      of blood glucose levels might be improved by the consumption of phloridzin, as 
      has been shown in recent clinical trials; these trials used phloridzin-enriched 
      apple extract at doses exceeding those from normal food consumption. There are, 
      however, indications that consumption of average to high levels of phloridzin via 
      food might also contribute to reduced sugar load and a reduction in T2DM risk.
FAU - Niederberger, Katherine E
AU  - Niederberger KE
AUID- ORCID: 0000-0001-9314-9864
AD  - Leveret GmbH, Baar, Switzerland.
FAU - Tennant, David R
AU  - Tennant DR
AD  - Food Chemical Risk Analysis, Sussex, UK.
FAU - Bellion, Phillip
AU  - Bellion P
AD  - DSM Nutritional Products, Kaiseraugst, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200108
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - CU9S17279X (Phlorhizin)
SB  - IM
MH  - Diabetes Mellitus, Type 2/prevention & control
MH  - *Food Analysis
MH  - Humans
MH  - Models, Biological
MH  - Phlorhizin/*administration & dosage/chemistry/*pharmacology
OTO - NOTNLM
OT  - Dietary intake
OT  - Dihydrochalcone
OT  - Phloridzin
OT  - Phlorizin
EDAT- 2020/01/09 06:00
MHDA- 2021/01/07 06:00
CRDT- 2020/01/09 06:00
PHST- 2020/01/09 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2020/01/09 06:00 [entrez]
AID - S0007114520000033 [pii]
AID - 10.1017/S0007114520000033 [doi]
PST - ppublish
SO  - Br J Nutr. 2020 Apr 28;123(8):942-950. doi: 10.1017/S0007114520000033. Epub 2020 
      Jan 8.