PMID- 31911283
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 410
DP  - 2020 Mar 15
TI  - A visual rating scale for cingulate island sign on 18F-FDG-PET to differentiate 
      dementia with Lewy bodies and Alzheimer's disease.
PG  - 116645
LID - S0022-510X(19)32410-4 [pii]
LID - 10.1016/j.jns.2019.116645 [doi]
AB  - Valid diagnosis of dementia with Lewy bodies (DLB) is essential to establish 
      appropriate treatment and care. However, the diagnostic accuracy is complicated 
      by clinical and pathological overlap with Alzheimer's disease (AD). Cingulate 
      island sign (CIS), defined as sparing of posterior cingulate cortex (PCC) 
      relative to precuneus and cuneus on 18F-fluoro-deoxy-glucose positron emission 
      tomography (18F-FDG-PET), is included in the revised diagnostic DLB criteria. 
      There are no guidelines for the visual grading of CIS, although visual rating is 
      a fast-applicable method in a clinical setting. The objective was to develop a 
      robust visual CIS scale and evaluate the performance in differentiating DLB with 
      and without amyloid beta pathology (Abeta+/-), and AD. 18F-FDG-PET scans from 35 DLB 
      patients, 36 AD patients, and 23 healthy controls were rated according to a 
      visual CIS scale based on specific reading criteria. The visual CIS scale was 
      validated against a quantitative CIS ratio derived from a region of interest 
      analysis of PCC, precuneus, and cuneus. DLB patients had a significantly higher 
      visual CIS score compared to AD patients, and controls. A cut-off visual CIS 
      score of 4 significantly differentiated DLB Abeta- patients from DLB Abeta+ patients. 
      In conclusion, the visual CIS scale is clinically useful to differentiate DLB 
      from AD. The degree of CIS may be related to Abeta pathology in DLB patients.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Gjerum, Le
AU  - Gjerum L
AD  - Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic 
      address: le.gjerum@regionh.dk.
FAU - Frederiksen, Kristian Steen
AU  - Frederiksen KS
AD  - Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Henriksen, Otto Molby
AU  - Henriksen OM
AD  - Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Law, Ian
AU  - Law I
AD  - Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Anderberg, Lasse
AU  - Anderberg L
AD  - Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Andersen, Birgitte Bo
AU  - Andersen BB
AD  - Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Bjerregaard, Eva
AU  - Bjerregaard E
AD  - Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Hejl, Anne-Mette
AU  - Hejl AM
AD  - Department of Neurology, Bispebjerg Hospital, University of Copenhagen, 
      Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark.
FAU - Hogh, Peter
AU  - Hogh P
AD  - Regional Dementia Research Center, Department of Neurology, Zealand University 
      Hospital, Sygehusvej 10, DK-4000 Roskilde, Denmark; Department of Clinical 
      Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
FAU - Hasselbalch, Steen Gregers
AU  - Hasselbalch SG
AD  - Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, 
      University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic 
      address: steen.gregers.hasselbalch@regionh.dk.
LA  - eng
PT  - Journal Article
DEP - 20191224
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Amyloid beta-Peptides)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - *Alzheimer Disease/diagnostic imaging
MH  - Amyloid beta-Peptides
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - *Lewy Body Disease/diagnostic imaging
MH  - Positron-Emission Tomography
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Cingulate island sign
OT  - Dementia with Lewy bodies
OT  - Dual pathology
OT  - FDG-PET
OT  - Visual rating scale
COIS- Declaration of Competing Interest All authors declare no conflicts of interest.
EDAT- 2020/01/09 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/01/09 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2019/12/17 00:00 [revised]
PHST- 2019/12/21 00:00 [accepted]
PHST- 2020/01/09 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/01/09 06:00 [entrez]
AID - S0022-510X(19)32410-4 [pii]
AID - 10.1016/j.jns.2019.116645 [doi]
PST - ppublish
SO  - J Neurol Sci. 2020 Mar 15;410:116645. doi: 10.1016/j.jns.2019.116645. Epub 2019 
      Dec 24.