PMID- 31912368
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 16
IP  - 2
DP  - 2020 Apr
TI  - The Dual Role of ROS in Hematological Malignancies: Stem Cell Protection and 
      Cancer Cell Metastasis.
PG  - 262-275
LID - 10.1007/s12015-019-09949-5 [doi]
AB  - BACKGROUND AND OBJECTIVE: Reactive oxygen species (ROS) play crucial role in 
      hematopoiesis, regulation of differentiation, self-renewal, and the balance 
      between quiescence and proliferation of hematopoietic stem cells (HSCs). The HSCs 
      are a small population of undifferentiated cells that reside in the bone marrow 
      (BM) and can undergo self-renewal by giving rise to mature cells. METHODS: 
      Relevant literature was identified through a PubMed search (2000-2019) of 
      English-language papers using the following terms: reactive oxygen species, 
      hematopoietic stem cell, leukemic stem cell, leukemia and chemotherapy. RESULTS: 
      HSCs are very sensitive to high levels of ROS and increased production of ROS 
      have been attributed to HSC aging. HSC aging induced by both cell intrinsic and 
      extrinsic factors is linked to impaired HSC self-renewal and regeneration. In 
      addition, the elevated ROS levels might even trigger differentiation of Leukemic 
      stem cells (LSCs) and ROS may be involved in the initiation and progression of 
      hematological malignancies, such as leukemia. CONCLUSION: Targeting genes 
      involved in ROS in LSCs and HSCs are increasingly being used as a critical target 
      for therapeutic interventions. Appropriate concentration of ROS may be an optimal 
      therapeutic target for treatment of leukemia during chemotherapy, but still more 
      studies are required to better understanding of the of ROS role in blood 
      disorders.
FAU - Samimi, Azin
AU  - Samimi A
AUID- ORCID: 0000-0003-4044-3351
AD  - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Legal Medicine Organization, Legal Medicine Research Center, Ahvaz, Iran.
FAU - Khodayar, Mohammad Javad
AU  - Khodayar MJ
AUID- ORCID: 0000-0001-9518-1286
AD  - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Alidadi, Hadis
AU  - Alidadi H
AUID- ORCID: 0000-0002-2623-0758
AD  - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Khodadi, Elahe
AU  - Khodadi E
AUID- ORCID: 0000-0002-3738-8454
AD  - Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran. khodadi.e@ajums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Cell Self Renewal
MH  - *Cytoprotection
MH  - Hematologic Neoplasms/drug therapy/genetics/*metabolism/pathology
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Neoplasm Metastasis
MH  - Reactive Oxygen Species/*metabolism
OTO - NOTNLM
OT  - Chemotherapy
OT  - Hematopoietic stem cell
OT  - Leukemic stem cell
OT  - Reactive oxygen species
EDAT- 2020/01/09 06:00
MHDA- 2021/06/04 06:00
CRDT- 2020/01/09 06:00
PHST- 2020/01/09 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2020/01/09 06:00 [entrez]
AID - 10.1007/s12015-019-09949-5 [pii]
AID - 10.1007/s12015-019-09949-5 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2020 Apr;16(2):262-275. doi: 10.1007/s12015-019-09949-5.