PMID- 31914078
OWN - NLM
STAT- MEDLINE
DCOM- 20200129
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 2
DP  - 2020 Jan
TI  - A cross-sectional study: Associations between sarcopenia and clinical 
      characteristics of patients with type 2 diabetes.
PG  - e18708
LID - 10.1097/MD.0000000000018708 [doi]
LID - e18708
AB  - Sarcopenia is a geriatric syndrome and it impairs physical function. Patients 
      with type 2 diabetes mellitus (T2DM) are at a higher risk of sarcopenia. The 
      purpose of this study is to explore characteristics of general information and 
      metabolic factors of sarcopenia in patients with T2DM in the northeast of China, 
      and provide information for the prevention and treatment of sarcopenia in 
      clinical practice.Patients with T2DM aged >/=65 were recruited in Changchun from 
      March 2017 to February 2018. Questionnaires of general information, physical 
      examination, laboratory and imaging examination were conducted. The patients were 
      assigned into sarcopenia group and non-sarcopenia group according to the 
      diagnostic criteria proposed by Asian working group for sarcopenia (AWGS), and 
      the differences between 2 groups were analyzed.A total of 132 participants were 
      included in this study, of which, 38 (28.8%) were diagnosed with sarcopenia. 94 
      (71.2%) were with no sarcopenia. Logistic regression analysis showed that age 
      (OR: 1.182, 95%CI: 1.038-1.346), trunk fat mass (TFM) (OR: 1.499, 95%CI: 
      1.146-1.960) and free thyroxine (FT4) (OR: 1.342, 95%CI: 1.102-1.635) were 
      independent risk factors for sarcopenia. BMI (body mass index) (OR: 0.365, 95%CI: 
      0.236-0.661), exercise (OR: 0.016, 95%CI: 0.001-0.169), female (OR: 0.000, 95%CI: 
      0.00-0.012), metformin (OR: 0.159, 95%CI: 0.026-0.967) and TSM (trunk skeletal 
      muscle mass) (OR: 0.395, 95%CI: 0.236-0.661) were protective factors for 
      sarcopenia.Sarcopenia in patients with T2DM is associated with increased age, 
      increased TFM and increased FT4 level. Regular exercise, female, metformin 
      administrations, high BMI and increased TSM are associated with lower risk of 
      sarcopenia.
FAU - Cui, Mengzhao
AU  - Cui M
AD  - Department of Endodcrinology and Metabolism of the First Hospital of Jilin 
      University, Changchun, Jilin Province, China.
FAU - Gang, Xiaokun
AU  - Gang X
FAU - Wang, Gang
AU  - Wang G
FAU - Xiao, Xianchao
AU  - Xiao X
FAU - Li, Zhuo
AU  - Li Z
FAU - Jiang, Zongmiao
AU  - Jiang Z
FAU - Wang, Guixia
AU  - Wang G
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 9100L32L2N (Metformin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Composition/physiology
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*physiopathology
MH  - Exercise/physiology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Metformin/therapeutic use
MH  - Muscle, Skeletal/physiopathology
MH  - Risk Factors
MH  - Sarcopenia/*epidemiology/*physiopathology
MH  - Sex Factors
MH  - Thyroxine/blood
PMC - PMC6959879
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/01/09 06:00
MHDA- 2020/01/30 06:00
PMCR- 2020/01/10
CRDT- 2020/01/09 06:00
PHST- 2020/01/09 06:00 [entrez]
PHST- 2020/01/09 06:00 [pubmed]
PHST- 2020/01/30 06:00 [medline]
PHST- 2020/01/10 00:00 [pmc-release]
AID - 00005792-202001100-00069 [pii]
AID - MD-D-19-03435 [pii]
AID - 10.1097/MD.0000000000018708 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jan;99(2):e18708. doi: 10.1097/MD.0000000000018708.