PMID- 31914442
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 102
IP  - 3
DP  - 2021
TI  - Effectiveness and Safety of Vonoprazan versus Proton Pump Inhibitors for 
      Second-Line Helicobacter pylori Eradication Therapy: Systematic Review and 
      Meta-Analysis.
PG  - 319-325
LID - 10.1159/000504939 [doi]
AB  - BACKGROUND: A novel potassium-competitive acid blocker, vonoprazan (VPZ), 
      improves first-line Helicobacter pylori eradication success. The aim of this 
      systematic review is to clarify the effectiveness and safety of second-line H. 
      pylori eradication therapy comparing VPZ and proton pump inhibitor (PPI)-based 
      regimens. METHODS: Medline (PubMed), EMBASE, Web of Science, Cochrane Library, 
      and the Japan Medical Abstract Society Database were searched. RESULTS: We 
      selected 16 studies for quantitative review. Forest plot analysis showed 
      significant superiority of VPZ over PPI-based regimens in overall second-line H. 
      pylori eradication success (OR 1.51, 95% CI 1.27-1.81, p < 0.001). Forest plots 
      from 2 studies with propensity score matched analysis showed significant 
      superiority of VPZ over PPI-based regimens (OR 3.09, 95% CI 1.71-5.58, p < 
      0.001). The remaining 14 studies with per-protocol analysis and the full analysis 
      set also showed significant superiority (OR 1.40, 95% CI 1.16-1.69, p < 0.001). 
      Regarding adverse events, Forest plot analysis did not show a significant 
      difference between the 2 regimens (OR 0.88, 95% CI 0.58-1.32, p = 0.53). 
      CONCLUSIONS: A VPZ-based regimen has significant superiority over a PPI-based 
      regimen for second-line H. pylori eradication therapy. A VPZ-based second-line H. 
      pylori eradication regimen can be the first choice.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Shinozaki, Satoshi
AU  - Shinozaki S
AD  - Shinozaki Medical Clinic, Utsunomiya, Japan, shinozaki-s@aqua.ocn.ne.jp.
AD  - Department of Medicine, Division of Gastroenterology, Jichi Medical University, 
      Shimotsuke, Japan, shinozaki-s@aqua.ocn.ne.jp.
FAU - Kobayashi, Yasutoshi
AU  - Kobayashi Y
AD  - Department of Medicine, Division of Gastroenterology, Jichi Medical University, 
      Shimotsuke, Japan.
FAU - Osawa, Hiroyuki
AU  - Osawa H
AD  - Department of Medicine, Division of Gastroenterology, Jichi Medical University, 
      Shimotsuke, Japan.
FAU - Sakamoto, Hirotsugu
AU  - Sakamoto H
AD  - Department of Medicine, Division of Gastroenterology, Jichi Medical University, 
      Shimotsuke, Japan.
FAU - Hayashi, Yoshikazu
AU  - Hayashi Y
AD  - Department of Medicine, Division of Gastroenterology, Jichi Medical University, 
      Shimotsuke, Japan.
FAU - Lefor, Alan Kawarai
AU  - Lefor AK
AD  - Department of Surgery, Jichi Medical University, Shimotsuke, Japan.
FAU - Yamamoto, Hironori
AU  - Yamamoto H
AD  - Department of Medicine, Division of Gastroenterology, Jichi Medical University, 
      Shimotsuke, Japan.
LA  - eng
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200108
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 
      (1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Pyrroles)
RN  - 0 (Sulfonamides)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Amoxicillin/therapeutic use
MH  - Anti-Bacterial Agents/adverse effects
MH  - Clarithromycin/therapeutic use
MH  - Drug Therapy, Combination
MH  - *Helicobacter Infections/drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Proton Pump Inhibitors/adverse effects
MH  - Pyrroles
MH  - Sulfonamides
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - Outcome measure
OT  - Potassium-competitive acid blocker
OT  - Proton pump inhibitor
OT  - Therapeutics
EDAT- 2020/01/09 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/01/09 06:00
PHST- 2019/08/22 00:00 [received]
PHST- 2019/11/21 00:00 [accepted]
PHST- 2020/01/09 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/01/09 06:00 [entrez]
AID - 000504939 [pii]
AID - 10.1159/000504939 [doi]
PST - ppublish
SO  - Digestion. 2021;102(3):319-325. doi: 10.1159/000504939. Epub 2020 Jan 8.