PMID- 31914445
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 1421-9832 (Electronic)
IS  - 1018-8665 (Linking)
VI  - 236
IP  - 4
DP  - 2020
TI  - Biological Sex and IgE Sensitization Influence Severity of Depression and 
      Cortisol Levels in Atopic Dermatitis.
PG  - 336-344
LID - 10.1159/000504388 [doi]
AB  - BACKGROUND: Depression is a common comorbid condition with atopic dermatitis 
      (AD), particularly during the active disease cycle. Controversial results 
      regarding the contribution of biological sex, immunoglobulin E (IgE) 
      sensitization, and cortisol on AD severity and comorbid depression justify 
      further investigation. OBJECTIVE AND METHODS: To explore the influence of sex and 
      IgE sensitization on biochemical and psychological parameters, and severity of 
      AD, a case-control study of 105 volunteers (56 AD, 49 healthy controls (HC); 50 
      males, 55 females) was conducted over 10 weeks, starting at dermatological 
      symptom onset. Disease severity, serum IgE, cortisol and testosterone levels, and 
      depression scores were assessed at study baseline and after 10 weeks of 
      conventional treatment. RESULTS: Dermatological severity differed among AD males 
      by IgE sensitization and was elevated in males with extrinsic atopic dermatitis 
      (EAD). Hamilton Depression Rating Scale (HAMD) scores were elevated in all 
      patients at study baseline and improved with symptom reduction to HC levels, 
      except female EAD. Severity of depression and dermatitis were correlated in EAD 
      males at baseline and at week 10. Serum cortisol was elevated in male EAD at 
      baseline, in contrast to males with intrinsic atopic dermatitis (IAD) at week 10. 
      In addition, cortisol levels were found negatively correlated with SCORAD and 
      HAMD scores in EAD males at week 10. CONCLUSION: Pathophysiological features of 
      AD and depression are likely related to different inflammation-based effects and 
      appear to be biological sex-dependent. Cortisol levels depend on biological sex 
      and IgE sensitization in AD and increase in males with EAD at exacerbation and 
      IAD males at resolution. Biological sex-related disease triggers, IgE 
      sensitization, and cortisol levels are important for the understanding of the 
      mechanisms underlying AD and comorbid depression.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Vinnik, Tatyana
AU  - Vinnik T
AD  - Department of Molecular Biology, Ariel University, Ariel, Israel, 
      tatyanavinnik15@gmail.com.
AD  - Department of Dermatovenereology, Astana Medical University, Nur-Sultan, 
      Kazakhstan, tatyanavinnik15@gmail.com.
FAU - Kreinin, Anatoly
AU  - Kreinin A
AD  - Maale HaCarmel Mental Health Center, Tirat HaCarmel, Israel.
FAU - Abildinova, Gulshara
AU  - Abildinova G
AD  - Medical Centre Hospital of the President's Affairs Administration of the Republic 
      of Kazakhstan, Nur-Sultan, Kazakhstan.
FAU - Batpenova, Gulnar
AU  - Batpenova G
AD  - Department of Dermatovenereology, Astana Medical University, Nur-Sultan, 
      Kazakhstan.
FAU - Kirby, Michael
AU  - Kirby M
AD  - Department of Molecular Biology, Ariel University, Ariel, Israel.
FAU - Pinhasov, Albert
AU  - Pinhasov A
AD  - Department of Molecular Biology, Ariel University, Ariel, Israel.
LA  - eng
PT  - Journal Article
DEP - 20200108
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3XMK78S47O (Testosterone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Depression/diagnosis/*immunology/psychology
MH  - Dermatitis, Atopic/blood/diagnosis/*immunology/*psychology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Hypersensitivity, Immediate/blood/*immunology/psychology
MH  - Immunoglobulin E/blood/*immunology
MH  - Male
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Testosterone/blood
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Cortisol
OT  - Depression
OT  - Immunoglobulin E
OT  - Testosterone
EDAT- 2020/01/09 06:00
MHDA- 2021/04/27 06:00
CRDT- 2020/01/09 06:00
PHST- 2019/09/13 00:00 [received]
PHST- 2019/10/25 00:00 [accepted]
PHST- 2020/01/09 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2020/01/09 06:00 [entrez]
AID - 000504388 [pii]
AID - 10.1159/000504388 [doi]
PST - ppublish
SO  - Dermatology. 2020;236(4):336-344. doi: 10.1159/000504388. Epub 2020 Jan 8.