PMID- 31915427
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 10
DP  - 2019
TI  - Neurochemical and Behavioral Profiling in Male and Female Rats of the Psychedelic 
      Agent 25I-NBOMe.
PG  - 1406
LID - 10.3389/fphar.2019.01406 [doi]
LID - 1406
AB  - 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe), commonly 
      called "N-Bomb," is a synthetic phenethylamine with psychedelic and entactogenic 
      effects; it was available on the Internet both as a legal alternative to lysergic 
      acid diethylamide (LSD) and as a surrogate of 3,4-methylenedioxy-methamphetamine 
      (MDMA), but now it has been scheduled among controlled substances. 25I-NBOMe acts 
      as full agonist on serotonergic 5-HT2A receptors. Users are often unaware of 
      ingesting fake LSD, and several cases of intoxication and fatalities have been 
      reported. In humans, overdoses of "N-Bomb" can cause tachycardia, hypertension, 
      seizures, and agitation. Preclinical studies have not yet widely investigated the 
      rewarding properties and behavioral effects of this compound in both sexes. 
      Therefore, by in vivo microdialysis, we evaluated the effects of 25I-NBOMe on 
      dopaminergic (DA) and serotonergic (5-HT) transmissions in the nucleus accumbens 
      (NAc) shell and core, and the medial prefrontal cortex (mPFC) of male and female 
      rats. Moreover, we investigated the effect of 25I-NBOMe on sensorimotor 
      modifications as well as body temperature, nociception, and startle/prepulse 
      inhibition (PPI). We showed that administration of 25I-NBOMe affects DA 
      transmission in the NAc shell in both sexes, although showing different patterns; 
      moreover, this compound causes impaired visual responses in both sexes, whereas 
      core temperature is heavily affected in females, and the highest dose tested 
      exerts an analgesic effect prominent in male rats. Indeed, this drug is able to 
      impair the startle amplitude with the same extent in both sexes and inhibits the 
      PPI in male and female rats. Our study fills the gap of knowledge on the 
      behavioral effects of 25I-NBOMe and the risks associated with its ingestion; it 
      focuses the attention on sex differences that might be useful to understand the 
      trend of consumption as well as to recognize and treat intoxication and overdose 
      symptoms.
CI  - Copyright (c) 2019 Miliano, Marti, Pintori, Castelli, Tirri, Arfe and De Luca.
FAU - Miliano, Cristina
AU  - Miliano C
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
FAU - Marti, Matteo
AU  - Marti M
AD  - National Institute of Neuroscience (INN), Universirty of Cagliari, Cagliari, 
      Italy.
AD  - Department of Morphology, Experimental Medicine and Surgery, Section of Legal 
      Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.
AD  - Collaborative Center for the Italian National Early Warning System, Department of 
      Anti-Drug Policies, Presidency of the Council of Ministers, Rome, Italy.
FAU - Pintori, Nicholas
AU  - Pintori N
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
FAU - Castelli, Maria Paola
AU  - Castelli MP
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
AD  - National Institute of Neuroscience (INN), Universirty of Cagliari, Cagliari, 
      Italy.
FAU - Tirri, Micaela
AU  - Tirri M
AD  - Department of Morphology, Experimental Medicine and Surgery, Section of Legal 
      Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.
FAU - Arfe, Raffaella
AU  - Arfe R
AD  - Department of Morphology, Experimental Medicine and Surgery, Section of Legal 
      Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.
AD  - Institute of Public Health, Section of Legal Medicine, Universita Cattolica del 
      Sacro Cuore, Rome, Italy.
FAU - De Luca, Maria Antonietta
AU  - De Luca MA
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
AD  - National Institute of Neuroscience (INN), Universirty of Cagliari, Cagliari, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20191212
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC6921684
OTO - NOTNLM
OT  - behavior
OT  - dopamine
OT  - novel psychoactive substances
OT  - serotonin
OT  - sex differences
EDAT- 2020/01/10 06:00
MHDA- 2020/01/10 06:01
PMCR- 2019/12/12
CRDT- 2020/01/10 06:00
PHST- 2019/08/01 00:00 [received]
PHST- 2019/11/05 00:00 [accepted]
PHST- 2020/01/10 06:00 [entrez]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2020/01/10 06:01 [medline]
PHST- 2019/12/12 00:00 [pmc-release]
AID - 10.3389/fphar.2019.01406 [doi]
PST - epublish
SO  - Front Pharmacol. 2019 Dec 12;10:1406. doi: 10.3389/fphar.2019.01406. eCollection 
      2019.