PMID- 31915470
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20220412
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2019
DP  - 2019
TI  - Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart 
      Disease.
PG  - 8473565
LID - 10.1155/2019/8473565 [doi]
LID - 8473565
AB  - BACKGROUND: We have previously shown that the deficiency of the gut enzyme 
      intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus 
      (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a 
      precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP 
      deficiency might also be associated with IHD in humans. We aimed to determine the 
      correlation between the IAP level and IHD in humans. METHODS AND RESULTS: The IHD 
      patients were recruited from the National Institute of Cardiovascular Diseases 
      (NICVD), Dhaka, Bangladesh, and the control healthy participants were recruited 
      from a suburban community of Dhaka. We determined the IAP level in the stools of 
      292 IHD patients (187 males, 105 females) and 331 healthy control people (84 
      males, 247 females). We found that compared to controls, IHD patients have 
      approx. 30% less IAP (mean +/- SEM: 63.7 +/- 3.5 vs. 44.9 +/- 2.1 U/g stool, 
      respectively; p < 0.000001), which indicates that IAP deficiency is associated 
      with IHD, and a high level of IAP is probably protective against IHD in humans. 
      The adjusted generalized linear model (GLM) of regression analysis predicted a 
      strong association of IAP with IHD (p = 0.0035). Multiple logistic regression 
      analysis showed an independent inverse relationship between the IAP level and the 
      IHD status (odds ratio, OR = 0.993 with 95% CI 0.987-0.998; p < 0.01). 
      CONCLUSIONS: IAP deficiency is associated with IHD, and a high level of IAP might 
      be protective against IHD.
CI  - Copyright (c) 2019 Jagannath Malo et al.
FAU - Malo, Jagannath
AU  - Malo J
AD  - National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.
FAU - Alam, Md Jahangir
AU  - Alam MJ
AD  - Department of Statistics, University of Rajshahi, Rajshahi, Bangladesh.
FAU - Shahnaz, Munjareen
AU  - Shahnaz M
AD  - Bangladesh Medical College, Dhaka 1209, Bangladesh.
FAU - Kaliannan, Kanakaraju
AU  - Kaliannan K
AD  - Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
FAU - Chandra, Gopal
AU  - Chandra G
AD  - National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.
FAU - Aziz, Tarek
AU  - Aziz T
AD  - National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.
FAU - Sarker, Tapas
AU  - Sarker T
AD  - National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.
FAU - Bala, Mihir
AU  - Bala M
AD  - National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.
FAU - Paul, Ratna
AU  - Paul R
AD  - Dhaka Medical College, Dhaka 1100, Bangladesh.
FAU - Saha, Chandan K
AU  - Saha CK
AD  - Shaheed Tajuddin Ahmad Medical College, Gazipur, Dhaka, Bangladesh.
FAU - Karmakar, Pradip K
AU  - Karmakar PK
AD  - National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.
FAU - Malo, Madhu S
AU  - Malo MS
AUID- ORCID: 0000-0002-2629-687X
AD  - MH Samorita Medical College, Dhaka 1208, Bangladesh.
AD  - Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh.
LA  - eng
PT  - Journal Article
DEP - 20191213
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 0 (GPI-Linked Proteins)
RN  - EC 3.1.3.1 (ALPI protein, human)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alkaline Phosphatase/deficiency/*genetics
MH  - Biomarkers/*metabolism
MH  - Case-Control Studies
MH  - *Down-Regulation
MH  - Feces/enzymology
MH  - Female
MH  - GPI-Linked Proteins/deficiency/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/diagnosis/*enzymology/genetics
PMC - PMC6930721
COIS- The authors declare no conflict of interests.
EDAT- 2020/01/10 06:00
MHDA- 2020/05/12 06:00
PMCR- 2019/12/13
CRDT- 2020/01/10 06:00
PHST- 2019/06/28 00:00 [received]
PHST- 2019/11/20 00:00 [revised]
PHST- 2019/11/30 00:00 [accepted]
PHST- 2020/01/10 06:00 [entrez]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/12/13 00:00 [pmc-release]
AID - 10.1155/2019/8473565 [doi]
PST - epublish
SO  - Dis Markers. 2019 Dec 13;2019:8473565. doi: 10.1155/2019/8473565. eCollection 
      2019.