PMID- 31915695
OWN - NLM
STAT- MEDLINE
DCOM- 20200624
LR  - 20231112
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Possible Effects of Proton Pump Inhibitors on Hearing Loss Development.
PG  - 4853695
LID - 10.1155/2019/4853695 [doi]
LID - 4853695
AB  - Considered safe and often available as over-the-counter (OTC) drugs, proton pump 
      inhibitors (PPI) are one of the most frequently used medicines. Over recent years 
      much research analyzing PPI has been conducted and these studies shed light on 
      PPI side effects and the mechanisms of these processes. In this study we 
      summarize the findings of these studies and through deduction present some 
      hypotheses on the impact of PPI on health. Of particular interest is the impact 
      of PPI on hearing loss development. However, despite this side effect being 
      localized, its mechanisms are complex, systemic and involve changes in whole 
      body. This paper summarizes how through, inter alia, alterations in the 
      circulatory system, respiratory system, central nervous system and metabolism PPI 
      can cause hearing impairment, which can occur in every age group and is connected 
      with long-term use of this group of drugs. This article also discusses the role 
      PPI plays in the acceleration of presbycusis development, in relation to the fact 
      that older people are the group who most frequently use PPI in long term. Hearing 
      loss negatively impacts affects quality of life, especially among older patients 
      who are also the most afflicted group; administration of PPI should therefore be 
      considered carefully, taking into consideration all potential benefits and side 
      effects.
CI  - Copyright (c) 2019 Michal Wicinski et al.
FAU - Wicinski, Michal
AU  - Wicinski M
AUID- ORCID: 0000-0002-7222-0171
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Malinowski, Bartosz
AU  - Malinowski B
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Puk, Oskar
AU  - Puk O
AUID- ORCID: 0000-0002-6659-2569
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Gorski, Karol
AU  - Gorski K
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Adamkiewicz, Dawid
AU  - Adamkiewicz D
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Chojnacki, Grzegorz
AU  - Chojnacki G
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Walczak, Maciej
AU  - Walczak M
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Wodkiewicz, Eryk
AU  - Wodkiewicz E
AUID- ORCID: 0000-0002-2834-3414
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Szambelan, Monika
AU  - Szambelan M
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Adamska, Paulina
AU  - Adamska P
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Skibinska, Kamila
AU  - Skibinska K
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Socha, Maciej
AU  - Socha M
AD  - Department of Obstetrics, Gynecology and Gynecological Oncology, Faculty of 
      Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Ujejskiego 75, 85-168 Bydgoszcz, Poland.
FAU - Slupski, Maciej
AU  - Slupski M
AD  - Department of Hepatobiliary and General Surgery, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Pawlak-Osinska, Katarzyna
AU  - Pawlak-Osinska K
AD  - Department of Pathophysiology of Hearing and Balance System, Collegium Medicum, 
      Nicolaus Copernicus University, Bydgoszcz, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191017
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Cardiovascular System/drug effects
MH  - Hearing Loss/*chemically induced
MH  - Humans
MH  - Immune System/drug effects
MH  - Metabolism/drug effects
MH  - Proton Pump Inhibitors/*adverse effects
PMC - PMC6935450
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2020/01/10 06:00
MHDA- 2020/06/25 06:00
PMCR- 2019/10/17
CRDT- 2020/01/10 06:00
PHST- 2019/02/05 00:00 [received]
PHST- 2019/05/24 00:00 [revised]
PHST- 2019/07/09 00:00 [accepted]
PHST- 2020/01/10 06:00 [entrez]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2020/06/25 06:00 [medline]
PHST- 2019/10/17 00:00 [pmc-release]
AID - 10.1155/2019/4853695 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Oct 17;2019:4853695. doi: 10.1155/2019/4853695. eCollection 
      2019.