PMID- 31916228
OWN - NLM
STAT- MEDLINE
DCOM- 20210802
LR  - 20210802
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 33
IP  - 4
DP  - 2020 Aug
TI  - Tubulointerstitial damage and interstitial immune cell phenotypes are useful 
      predictors for renal survival and relapse in antineutrophil cytoplasmic 
      antibody-associated vasculitis.
PG  - 771-781
LID - 10.1007/s40620-019-00695-y [doi]
AB  - The aims of this study were to determine whether tubulointerstitial damage in the 
      form of interstitial fibrosis/tubular atrophy and total interstitial inflammation 
      predicted progression to end stage renal disease (ESRD) and/or renal relapse (RR) 
      in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). 
      One hundred thirteen patients with AAV from six French centers with an index 
      biopsy performed between 2003 and 2013 were included. Histological assessments 
      using the AAV glomerular classification and the kidney allograft Banff 
      classification were performed on pathological review. Biopsy tissues were also 
      investigated by CD3, CD20, CD68, CD163, FOXP3 and RORgammat immunohistochemical 
      staining. Competing risks models were calculated. Of the 113 patients, 26 (23.0%) 
      died during follow-up and 29 (25.6%) developed ESRD. Among the 94 patients who 
      achieved remission by the end of induction therapy without developing ESRD, 26 
      (27.6%) experienced RR. The two independent prognostic factors for ESRD were the 
      estimated glomerular filtration rate at presentation (HR 0.35; 95% CI 0.23-0.51; 
      P < 0.0001) and IF/TA > 25% (HR 2.27; 95% CI 1.18-4.37; P = 0.014). When the 
      distribution of interstitial immune cell phenotypes was included in a second 
      multivariable model, the organization of lymphocytic infiltrates was also an 
      independent predictor of ESRD (HR 2.86; 95% CI 1.35-6.1, P = 0.006). The 
      independent risk factors for RR were a higher CD3/CD20 ratio (HR 1.39; 95% CI 
      1.05-1.85; P = 0.02) and the presence of RORgammat positive cells (HR 2.70; 95% CI 
      1.11-6.54; P = 0.02). Our results highlight the prognostic value of initial 
      histological evaluations in AAV. Measurements of tubulointerstitial damage and 
      interstitial immune cell phenotype distributions should be considered to improve 
      risk assessments for ESRD and RR.
FAU - Bitton, Laura
AU  - Bitton L
AD  - Pathology Department, AP-HP, Hopital Tenon, 75020, Paris, France.
FAU - Vandenbussche, Cyrille
AU  - Vandenbussche C
AD  - Nephrology and Internal Medicine Department, Hospital of Valenciennes, 59322, 
      Valenciennes, France.
FAU - Wayolle, Nicolas
AU  - Wayolle N
AD  - Nephrology Department, Univ. Lille, CHU Lille, 59000, Lille, France.
FAU - Gibier, Jean-Baptiste
AU  - Gibier JB
AD  - Pathology Department, Lille University Hospital (CHU), Pathology Institute, 
      Inserm UMR-S1172 Lille, JPARC-Jean-Pierre Aubert Research Center, Team 'Mucins, 
      Epithelial Differentiation and Carcinogenesis", Lille University, CHU Lille, 
      Avenue Oscar Lambret, 59000, Lille, France.
FAU - Cordonnier, Carole
AU  - Cordonnier C
AD  - Pathology Department, Amiens University Hospital, 80054, Amiens, France.
FAU - Verine, Jerome
AU  - Verine J
AD  - Hopital Saint-Louis Pathology Department, AP-HP, 75010, Paris, France.
FAU - Humez, Sarah
AU  - Humez S
AD  - Pathology Department, CNRS, Institut Pasteur de Lille, UMR 8161-M3T "Mechanisms 
      of Tumorigenesis and Targeted Therapies", Univ. Lille, CHU Lille, 59000, Lille, 
      France.
FAU - Bataille, Pierre
AU  - Bataille P
AD  - Nephrology Department, Hospital of Boulogne-Sur-Mer, 62200, Boulogne-sur-Mer, 
      France.
FAU - Lenain, Remi
AU  - Lenain R
AD  - EA 2694-Sante Publique : epidemiologie Et qualite Des Soins, Univ. Lille, CHU 
      Lille, 59000, Lille, France.
FAU - Ramdane, Nassima
AU  - Ramdane N
AD  - EA 2694-Sante Publique : epidemiologie Et qualite Des Soins, Univ. Lille, CHU 
      Lille, 59000, Lille, France.
FAU - Azar, Raymond
AU  - Azar R
AD  - Nephrology Department, Hospital of Dunkerque, 59385, Dunkerque, France.
FAU - Mac Namara, Evelyne
AU  - Mac Namara E
AD  - Nephrology Department, Hospital of Bethune-Beuvry, 62408, Bethune, France.
FAU - Hatron, Pierre-Yves
AU  - Hatron PY
AD  - Internal Medicine Department, Univ. Lille, CHU Lille, 59000, Lille, France.
FAU - Maurage, Claude-Alain
AU  - Maurage CA
AD  - Pathology Department, Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPARC - 
      Jean-Pierre Aubert Research Center, Team "Alzheimer & Tauopathies", 59000, Lille, 
      France.
FAU - Perrais, Michael
AU  - Perrais M
AD  - Pathology Department, Lille University Hospital (CHU), Pathology Institute, 
      Inserm UMR-S1172 Lille, JPARC-Jean-Pierre Aubert Research Center, Team 'Mucins, 
      Epithelial Differentiation and Carcinogenesis", Lille University, CHU Lille, 
      Avenue Oscar Lambret, 59000, Lille, France.
FAU - Frimat, Marie
AU  - Frimat M
AD  - Nephrology Department, Univ. Lille, CHU Lille, 59000, Lille, France.
FAU - Vanhille, Philippe
AU  - Vanhille P
AD  - Nephrology and Internal Medicine Department, Hospital of Valenciennes, 59322, 
      Valenciennes, France.
FAU - Glowacki, Francois
AU  - Glowacki F
AD  - Nephrology Department, Univ. Lille, CHU Lille, 59000, Lille, France.
FAU - Buob, David
AU  - Buob D
AD  - Pathology Department, AP-HP, Hopital Tenon, 75020, Paris, France.
FAU - Copin, Marie-Christine
AU  - Copin MC
AD  - Pathology Department, CNRS, Institut Pasteur de Lille, UMR 8161-M3T "Mechanisms 
      of Tumorigenesis and Targeted Therapies", Univ. Lille, CHU Lille, 59000, Lille, 
      France.
FAU - Quemeneur, Thomas
AU  - Quemeneur T
AD  - Nephrology and Internal Medicine Department, Hospital of Valenciennes, 59322, 
      Valenciennes, France.
FAU - Gnemmi, Viviane
AU  - Gnemmi V
AUID- ORCID: 0000-0001-7403-4607
AD  - Pathology Department, Lille University Hospital (CHU), Pathology Institute, 
      Inserm UMR-S1172 Lille, JPARC-Jean-Pierre Aubert Research Center, Team 'Mucins, 
      Epithelial Differentiation and Carcinogenesis", Lille University, CHU Lille, 
      Avenue Oscar Lambret, 59000, Lille, France. viviane.gnemmi@univ-lille.fr.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200108
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology/pathology
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Humans
MH  - Kidney/pathology
MH  - *Kidney Failure, Chronic/immunology/pathology
MH  - Kidney Tubules/immunology/pathology
MH  - Phenotype
MH  - Recurrence
MH  - Retrospective Studies
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Fibrosis
OT  - Interstitial lymphocytic organization
OT  - Macrophage
OT  - Renal relapse
OT  - Th17
EDAT- 2020/01/10 06:00
MHDA- 2021/08/03 06:00
CRDT- 2020/01/10 06:00
PHST- 2019/09/27 00:00 [received]
PHST- 2019/12/26 00:00 [accepted]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2021/08/03 06:00 [medline]
PHST- 2020/01/10 06:00 [entrez]
AID - 10.1007/s40620-019-00695-y [pii]
AID - 10.1007/s40620-019-00695-y [doi]
PST - ppublish
SO  - J Nephrol. 2020 Aug;33(4):771-781. doi: 10.1007/s40620-019-00695-y. Epub 2020 Jan 
      8.