PMID- 31916474
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 32
IP  - 8
DP  - 2021 Dec
TI  - Targeting of keloid with TRAIL and TRAIL-R2/DR5.
PG  - 957-964
LID - 10.1080/09546634.2020.1714541 [doi]
AB  - Keloid is a common and frequently-occurring disease in plastic surgery, and its 
      ugly appearance and itching symptoms bring mental and life pain to patients. 
      However, the clinical treatment of keloid, such as drug injection treatment, 
      surgical resection, cryotherapy, laser treatment and other therapeutic effects 
      are poor. Since the discovery of tumor necrosis factor related apoptosis inducing 
      ligand (TRAIL) in 1995, its selective apoptosis on tumor cells makes it have a 
      great prospect in the targeted treatment of tumor. In recent years, it has been 
      found that the formation of keloid is related to the imbalance of apoptosis of 
      fibroblasts in scar and the binding of TRAI to its receptor mediates the 
      apoptosis of fibroblasts. Therefore, the use of TRAIL and TRAIL-R2/death receptor 
      5 (DR5) in the treatment of keloid has become a hot research topic. In this 
      paper, the present situation, mechanism and development prospect of TRAIL and 
      TRAIL-R2/DR5 targeted treatment of keloid were reviewed, which provided a 
      reference for promoting the development of keloid treatment.
FAU - Sun, Pengfei
AU  - Sun P
AD  - Department of Plastic Surgery, Zibo Central Hospital, Zibo, China.
FAU - Hu, Zhensheng
AU  - Hu Z
AD  - Department of Plastic Surgery, Qilu Hospital of Shandong University, Jinan, 
      China.
FAU - Pan, Bo
AU  - Pan B
AD  - Department of Plastic Surgery, Plastic Surgery Hospital, Peking Union Medical 
      College, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Lu, Xiaosheng
AU  - Lu X
AD  - Department of Plastic Surgery, Affiliated Hospital of Weifang Medical University, 
      Weifang, China.
LA  - eng
PT  - Journal Article
DEP - 20200120
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
SB  - IM
MH  - Apoptosis
MH  - Cell Line, Tumor
MH  - Fibroblasts
MH  - Humans
MH  - *Keloid/drug therapy
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand
MH  - TNF-Related Apoptosis-Inducing Ligand
OTO - NOTNLM
OT  - DR5
OT  - Keloid
OT  - TRAIL
OT  - targeted therapy
EDAT- 2020/01/10 06:00
MHDA- 2021/11/30 06:00
CRDT- 2020/01/10 06:00
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2020/01/10 06:00 [entrez]
AID - 10.1080/09546634.2020.1714541 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2021 Dec;32(8):957-964. doi: 10.1080/09546634.2020.1714541. 
      Epub 2020 Jan 20.