PMID- 31917242
OWN - NLM
STAT- MEDLINE
DCOM- 20210526
LR  - 20210526
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 381
DP  - 2020 Mar 2
TI  - Maternal deprivation impairs memory and cognitive flexibility, effect that is 
      avoided by environmental enrichment.
PG  - 112468
LID - S0166-4328(19)31070-8 [pii]
LID - 10.1016/j.bbr.2020.112468 [doi]
AB  - Maternal deprivation (MD) causes cognitive deficits that persist until adulthood. 
      Thereby, the environmental enrichment (EE) is widely used to increase brain 
      plasticity. Here, pregnant female rats were used and their offspring were 
      submitted to neonatal MD from post-natal day 1-10; after weaning the rats were 
      submitted to EE. MD caused deficits on short and long-term aversive and 
      recognition memory and on cognitive flexibility tested on reversed Morris Water 
      Maze test. MD also promoted the decrease of hippocampal Brain-Derived Neurotropic 
      Factor (BDNF) protein expression. The EE was able to protect against the 
      cognitive deficits, avoiding the memory and the cognitive flexibility disrupting, 
      and normalizing hippocampal BDNF expression of rats submitted to MD. These data 
      confirms that MD promotes long-life memory deficits and demonstrates that MD 
      causes cognitive flexibility disruption; the mechanisms seem involve the decrease 
      of BDNF. We also demonstrate that EE, which improves BDNF, is able to avoid 
      memory deficits and cognitive flexibility disrupts.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Menezes, Jefferson
AU  - Menezes J
AD  - Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of 
      Pampa, Uruguaiana, RS, Brazil.
FAU - Souto das Neves, Ben-Hur
AU  - Souto das Neves BH
AD  - Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of 
      Pampa, Uruguaiana, RS, Brazil.
FAU - Goncalves, Rithiele
AU  - Goncalves R
AD  - Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of 
      Pampa, Uruguaiana, RS, Brazil.
FAU - Benetti, Fernando
AU  - Benetti F
AD  - Laboratorio de Neurofisiologia da Cognicao e do Desenvolvimento, Departamento de 
      Fisiologia, Instituto de Ciencias Basicas da Saude - ICBS, Universidade Federal 
      do Rio Grande do Sul, Rua Sarmento Leite, 500 Porto Alegre, RS, Brazil.
FAU - Mello-Carpes, Pamela Billig
AU  - Mello-Carpes PB
AD  - Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of 
      Pampa, Uruguaiana, RS, Brazil. Electronic address: pamelacarpes@unipampa.edu.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200107
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*physiology
MH  - Elevated Plus Maze Test
MH  - Hippocampus/*metabolism
MH  - *Housing, Animal
MH  - *Maternal Deprivation
MH  - Memory/*physiology
MH  - Memory Consolidation
MH  - Memory, Long-Term
MH  - Memory, Short-Term
MH  - Morris Water Maze Test
MH  - Neuronal Plasticity
MH  - Open Field Test
MH  - Rats
MH  - Recognition, Psychology
OTO - NOTNLM
OT  - Aversive memory
OT  - BDNF
OT  - Neuroplasticity
OT  - Recognition memory
EDAT- 2020/01/10 06:00
MHDA- 2021/05/27 06:00
CRDT- 2020/01/10 06:00
PHST- 2019/07/09 00:00 [received]
PHST- 2020/01/03 00:00 [revised]
PHST- 2020/01/03 00:00 [accepted]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2021/05/27 06:00 [medline]
PHST- 2020/01/10 06:00 [entrez]
AID - S0166-4328(19)31070-8 [pii]
AID - 10.1016/j.bbr.2020.112468 [doi]
PST - ppublish
SO  - Behav Brain Res. 2020 Mar 2;381:112468. doi: 10.1016/j.bbr.2020.112468. Epub 2020 
      Jan 7.