PMID- 31918130
OWN - NLM
STAT- MEDLINE
DCOM- 20200612
LR  - 20200612
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 259
DP  - 2020 Apr
TI  - Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure 
      induces hepatic steatosis in male mice.
PG  - 113820
LID - S0269-7491(19)35724-0 [pii]
LID - 10.1016/j.envpol.2019.113820 [doi]
AB  - Environmental exposure to 2,3,7,8-tetrachlorodibenzofuran (TCDF), one of typical 
      persistent organic pollutants (POPs) produced from municipal waste combustion, 
      exerts toxic effects on human healthy. In the current study, we mainly used 
      targeted metabolomics combined with untargeted (1)H NMR-based metabolomics to 
      investigate the effects of TCDF exposure on lipid homeostasis in mice. We found 
      that TCDF exposure induced hepatic lipogenesis, the early-stage of non-alcoholic 
      fatty liver disease, manifested by excessive lipids including triglycerides, 
      fatty acids and lipotoxic ceramides accumulated in the liver together with 
      elevated serum very low-density lipoprotein by activating the aryl hydrocarbon 
      receptor (AHR) and its target genes such as Cyp1a1 and Cd36. We also found that 
      TCDF exposure induced alteration of phospholipids and choline metabolites and 
      endoplasmic reticulum (ER) markers in the liver of mice, indicating that 
      disruption of host cell membrane structural integrity and ER stress leading to 
      hepatic steatosis. In addition, complementary information was also obtained from 
      histopathologic assessments and biological assays, strongly supporting toxic 
      effects of TCDF. These results provide new evidence of TCDF toxicity associated 
      with fatty liver disease and further our understanding of health effects of 
      environmental pollutants exposure.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Yuan, Peihong
AU  - Yuan P
AD  - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China; CAS Key Laboratory 
      of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic 
      Resonance and Atomic and Molecular Physics, National Centre for Magnetic 
      Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation 
      Academy for Precision Measurement Science and Technology, Chinese Academy of 
      Sciences (CAS), Wuhan 430071, China.
FAU - Dong, Manyuan
AU  - Dong M
AD  - CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key 
      Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National 
      Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and 
      Mathematics, Innovation Academy for Precision Measurement Science and Technology, 
      Chinese Academy of Sciences (CAS), Wuhan 430071, China; University of Chinese 
      Academy of Sciences, Beijing 100049, China.
FAU - Lei, Hehua
AU  - Lei H
AD  - CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key 
      Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National 
      Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and 
      Mathematics, Innovation Academy for Precision Measurement Science and Technology, 
      Chinese Academy of Sciences (CAS), Wuhan 430071, China.
FAU - Xu, Guangyong
AU  - Xu G
AD  - CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key 
      Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National 
      Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and 
      Mathematics, Innovation Academy for Precision Measurement Science and Technology, 
      Chinese Academy of Sciences (CAS), Wuhan 430071, China; School of Environmental 
      and Safety Engineering, Changzhou University, Jiangsu, 213164, China.
FAU - Chen, Gui
AU  - Chen G
AD  - CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key 
      Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National 
      Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and 
      Mathematics, Innovation Academy for Precision Measurement Science and Technology, 
      Chinese Academy of Sciences (CAS), Wuhan 430071, China; University of Chinese 
      Academy of Sciences, Beijing 100049, China.
FAU - Song, Yuchen
AU  - Song Y
AD  - CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key 
      Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National 
      Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and 
      Mathematics, Innovation Academy for Precision Measurement Science and Technology, 
      Chinese Academy of Sciences (CAS), Wuhan 430071, China; University of Chinese 
      Academy of Sciences, Beijing 100049, China.
FAU - Ma, Jianfeng
AU  - Ma J
AD  - School of Environmental and Safety Engineering, Changzhou University, Jiangsu, 
      213164, China.
FAU - Cheng, Liming
AU  - Cheng L
AD  - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Zhang, Limin
AU  - Zhang L
AD  - CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key 
      Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National 
      Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and 
      Mathematics, Innovation Academy for Precision Measurement Science and Technology, 
      Chinese Academy of Sciences (CAS), Wuhan 430071, China; Wuhan National Research 
      Center for Optoelectronics, Wuhan 430071, China. Electronic address: 
      zhanglm@wipm.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20191228
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Benzofurans)
RN  - XZJ41GQI5D (2,3,7,8-tetrachlorodibenzofuran)
SB  - IM
MH  - Animals
MH  - Benzofurans/*toxicity
MH  - Fatty Liver/*chemically induced
MH  - Humans
MH  - Liver
MH  - Male
MH  - Metabolomics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Non-alcoholic Fatty Liver Disease
OTO - NOTNLM
OT  - 2,3,7,8-Tetrachlorodibenzofuran (TCDF)
OT  - Hepatic steatosis
OT  - Metabolomics
OT  - The aryl hydrocarbon receptor
COIS- Declaration of competing interest The authors have declared that no competing 
      interests exist.
EDAT- 2020/01/10 06:00
MHDA- 2020/06/13 06:00
CRDT- 2020/01/10 06:00
PHST- 2019/10/03 00:00 [received]
PHST- 2019/12/14 00:00 [revised]
PHST- 2019/12/14 00:00 [accepted]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2020/06/13 06:00 [medline]
PHST- 2020/01/10 06:00 [entrez]
AID - S0269-7491(19)35724-0 [pii]
AID - 10.1016/j.envpol.2019.113820 [doi]
PST - ppublish
SO  - Environ Pollut. 2020 Apr;259:113820. doi: 10.1016/j.envpol.2019.113820. Epub 2019 
      Dec 28.