PMID- 31918258
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20200408
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 190
DP  - 2020 Mar 1
TI  - Effects of metal contamination on liver in two fish species from a highly 
      impacted neotropical river: A case study of the Fundao dam, Brazil.
PG  - 110165
LID - S0147-6513(20)30004-X [pii]
LID - 10.1016/j.ecoenv.2020.110165 [doi]
AB  - Environmental disasters such as the rupturing of mine tailings dams are a major 
      concern worldwide. In the present study, we assess the effects of the release of 
      mine waste due to the rupture of the Fundao dam on two native fish species 
      (Hoplias intermedius and Hypostomus affinis) from the Doce River basin. Two 
      sampling sites were chosen: S1, a reference site, and S2, contaminated by mining 
      waste. Water and sediment were collected to evaluate metals concentration. Adult 
      fish were caught to analyse biological parameters, hepatic histopathology, and 
      biomarkers of metal contamination. Compared to site S1, the concentration of 
      manganese was statistically higher in water while lead, nickel, and arsenic were 
      statistically higher in the sediment from site S2, and iron had no significant 
      difference between sites. At site S1, fish of both species presented hepatic 
      tissue with normal architecture. At site S2, hepatic alterations, such as 
      cytoplasmic vacuolization and necrosis were frequently found in both species. 
      Regarding the histopathological index, higher values were found in both species 
      from site S2. The positive antibody reactions for cytochrome P450 1A (CYP1A) and 
      metallothionein (MT) were statistically greater in site S2 for both species. The 
      oxidative stress biomarkers, superoxide dismutase (SOD) and catalase (CAT) were 
      statistically higher in H. intermedius from site S2, but only CAT was 
      statistically greater in H. affinis at site S2. These results demonstrate that 
      the release of mineral residues from the rupture of the Samarco mine dam is 
      provoking hepatic damage in the fish from the Doce River besides inducing the 
      expression of proteins and enzymes related to metal contamination.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Weber, Andre Alberto
AU  - Weber AA
AD  - Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, UFMG, Belo Horizonte, C.P.486, 30161-970, Minas Gerais, 
      Brazil.
FAU - Sales, Camila Ferreira
AU  - Sales CF
AD  - Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, UFMG, Belo Horizonte, C.P.486, 30161-970, Minas Gerais, 
      Brazil.
FAU - de Souza Faria, Francisco
AU  - de Souza Faria F
AD  - Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, UFMG, Belo Horizonte, C.P.486, 30161-970, Minas Gerais, 
      Brazil.
FAU - Melo, Rafael Magno Costa
AU  - Melo RMC
AD  - Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, UFMG, Belo Horizonte, C.P.486, 30161-970, Minas Gerais, 
      Brazil.
FAU - Bazzoli, Nilo
AU  - Bazzoli N
AD  - Programa de Pos-graduacao em Zoologia de Vertebrados, Pontificia Universidade 
      Catolica de Minas Gerais, PUC Minas, Belo Horizonte, 30535-610, Minas Gerais, 
      Brazil.
FAU - Rizzo, Elizete
AU  - Rizzo E
AD  - Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, UFMG, Belo Horizonte, C.P.486, 30161-970, Minas Gerais, 
      Brazil. Electronic address: ictio@icb.ufmg.br.
LA  - eng
PT  - Journal Article
DEP - 20200106
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Industrial Waste)
RN  - 0 (Metals, Heavy)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Arsenic/analysis/*toxicity
MH  - Brazil
MH  - Catalase/metabolism
MH  - Catfishes/*metabolism
MH  - Characiformes/*metabolism
MH  - Environmental Monitoring
MH  - Industrial Waste
MH  - Liver/*drug effects/metabolism/pathology
MH  - Metals, Heavy/analysis/*toxicity
MH  - Mining
MH  - Rivers/chemistry
MH  - Superoxide Dismutase/metabolism
MH  - Water Pollutants, Chemical/analysis/*toxicity
OTO - NOTNLM
OT  - Doce river
OT  - Hoplias intermedius
OT  - Hypostomus affinis
OT  - Metallothionein
OT  - Oxidative stress
EDAT- 2020/01/10 06:00
MHDA- 2020/04/09 06:00
CRDT- 2020/01/10 06:00
PHST- 2019/10/09 00:00 [received]
PHST- 2019/12/13 00:00 [revised]
PHST- 2020/01/02 00:00 [accepted]
PHST- 2020/01/10 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2020/01/10 06:00 [entrez]
AID - S0147-6513(20)30004-X [pii]
AID - 10.1016/j.ecoenv.2020.110165 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2020 Mar 1;190:110165. doi: 10.1016/j.ecoenv.2020.110165. 
      Epub 2020 Jan 6.