PMID- 31918391 OWN - NLM STAT- MEDLINE DCOM- 20210119 LR - 20210302 IS - 1873-3360 (Electronic) IS - 0306-4530 (Print) IS - 0306-4530 (Linking) VI - 113 DP - 2020 Mar TI - Changes in appetite-regulating hormones following food intake are associated with changes in reported appetite and a measure of hedonic eating in girls and young women with anorexia nervosa. PG - 104556 LID - S0306-4530(19)31297-1 [pii] LID - 10.1016/j.psyneuen.2019.104556 [doi] AB - BACKGROUND: Females with anorexia nervosa (AN) have higher ghrelin and peptide YY (PYY) and lower brain-derived neurotropic factor (BDNF) levels than controls, and differ in their perception of hunger cues. Studies have not examined appetite-regulating hormones in the context of homeostatic and hedonic appetite in AN. OBJECTIVE: To examine whether alterations in appetite-regulating hormones following a standardized meal are associated with homeostatic and hedonic appetite in young females with AN vs. controls. METHODS: 68 females (36 AN, 32 controls) 10-22 years old were enrolled. Ghrelin, PYY and BDNF levels were assessed before, and 30, 60 and 120 min following a 400-kilocalorie standardized breakfast. Visual Analog Scales (VAS) assessing prospective food consumption, hunger, satiety, and hedonic appetite were administered before and 20 min after breakfast. A Cookie Taste Test (CTT) was conducted after a snack as a measure of hedonic eating behavior approximately 3 h after breakfast. RESULTS: AN had higher fasting ghrelin and PYY, and lower fasting BDNF (p = 0.001, 0.002 and 0.044 respectively) than controls. Following breakfast (over 120 min), ghrelin and PYY area under the curve (AUC) were higher, while BDNF AUC was lower in AN vs. controls (p = 0.007, 0.017 and 0.020 respectively). Among AN (but not controls), reductions in ghrelin and increases in PYY in the first 30-minutes following breakfast were associated with reductions in VAS scores for prospective food consumption. AN consumed fewer calories during the CTT vs. controls (p < 0.0001). In AN (particularly AN-restrictive subtype), BDNF AUC was positively associated with kilocalories consumed during the CTT CONCLUSIONS: In young females with AN, changes in ghrelin and PYY following food intake are associated with reductions in a prospective measure of food consumption, while reductions in BDNF are associated with reduced hedonic food intake. Further studies are necessary to better understand the complex interplay between appetite signals and eating behaviors in AN. CI - Copyright (c) 2019 Elsevier Ltd. All rights reserved. FAU - Mancuso, Christopher AU - Mancuso C AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Izquierdo, Alyssa AU - Izquierdo A AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Slattery, Meghan AU - Slattery M AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Becker, Kendra R AU - Becker KR AD - Eating Disorders Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Plessow, Franziska AU - Plessow F AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Thomas, Jennifer J AU - Thomas JJ AD - Eating Disorders Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Eddy, Kamryn T AU - Eddy KT AD - Eating Disorders Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Lawson, Elizabeth A AU - Lawson EA AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, United States. FAU - Misra, Madhusmita AU - Misra M AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, United States; Division of Pediatric Endocrinology, Massachusetts General Hospital for Children and Harvard Medical School, United States. Electronic address: mmisra@mgh.harvard.edu. LA - eng GR - R56 DK050561/DK/NIDDK NIH HHS/United States GR - R01 DK050561/DK/NIDDK NIH HHS/United States GR - K24 HD071843/HD/NICHD NIH HHS/United States GR - R01 MH103402/MH/NIMH NIH HHS/United States GR - F32 MH111127/MH/NIMH NIH HHS/United States GR - K24 MH120568/MH/NIMH NIH HHS/United States GR - P30 DK040561/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20191223 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Ghrelin) RN - 106388-42-5 (Peptide YY) SB - IM MH - Adolescent MH - Anorexia Nervosa/*metabolism/psychology MH - Appetite/*physiology MH - Brain-Derived Neurotrophic Factor/analysis MH - Child MH - Eating/physiology MH - Fasting/physiology MH - Feeding Behavior/*psychology MH - Female MH - Ghrelin/analysis MH - Humans MH - Hunger/physiology MH - Peptide YY/analysis MH - Prospective Studies MH - Young Adult PMC - PMC7080573 MID - NIHMS1548795 OTO - NOTNLM OT - Anorexia nervosa OT - Appetite OT - BDNF OT - Ghrelin OT - PYY OT - Visual analog scale COIS- Declaration of Competing Interest The authors declare that there are no conflicts of interest. EDAT- 2020/01/10 06:00 MHDA- 2021/01/20 06:00 PMCR- 2021/03/01 CRDT- 2020/01/10 06:00 PHST- 2019/04/23 00:00 [received] PHST- 2019/11/11 00:00 [revised] PHST- 2019/12/13 00:00 [accepted] PHST- 2020/01/10 06:00 [pubmed] PHST- 2021/01/20 06:00 [medline] PHST- 2020/01/10 06:00 [entrez] PHST- 2021/03/01 00:00 [pmc-release] AID - S0306-4530(19)31297-1 [pii] AID - 10.1016/j.psyneuen.2019.104556 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2020 Mar;113:104556. doi: 10.1016/j.psyneuen.2019.104556. Epub 2019 Dec 23.