PMID- 31919124
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20230829
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jan 8
TI  - Outcomes of HIV treatment from the private sector in low-income and middle-income 
      countries: a systematic review protocol.
PG  - e031844
LID - 10.1136/bmjopen-2019-031844 [doi]
LID - e031844
AB  - INTRODUCTION: Private sector provision of HIV treatment is increasing in 
      low-income and middle-income countries (LMIC). However, there is limited 
      documentation of its outcomes. This protocol reports a proposed systematic review 
      that will synthesise clinical outcomes of private sector HIV treatment in LMIC. 
      METHODS AND ANALYSIS: This review will be conducted in accordance with the 
      preferred reporting items for systematic review and meta-analyses protocols. 
      Primary outcomes will include: (1) proportion of eligible patients initiating 
      antiretroviral therapy (ART); (2) proportion of those on ART with <1000 
      copies/mL; (3) rate of all-cause mortality among ART recipients. Secondary 
      outcomes will include: (1) proportion receiving Pneumocystis jiroveci pneumonia 
      prophylaxis; (2) proportion with >90% ART adherence (based on any measure 
      reported); (3) proportion screened for non-communicable diseases (specifically 
      cervical cancer, diabetes, hypertension and mental ill health); (iv) proportion 
      screened for tuberculosis. A search of five electronic bibliographical databases 
      (Embase, Medline, PsychINFO, Web of Science and CINAHL) and reference lists of 
      included articles will be conducted to identify relevant articles reporting HIV 
      clinical outcomes. Searches will be limited to LMIC. No age, publication date, 
      study-design or language limits will be applied. Authors of relevant studies will 
      be contacted for clarification. Two reviewers will independently screen citations 
      and abstracts, identify full text articles for inclusion, extract data and 
      appraise the quality and bias of included studies. Outcome data will be pooled to 
      generate aggregative proportions of primary and secondary outcomes. Descriptive 
      statistics and a narrative synthesis will be presented. Heterogeneity and 
      sensitivity assessments will be conducted to aid interpretation of results. 
      ETHICS AND DISSEMINATION: The results of this review will be disseminated through 
      a peer-reviewed scientific manuscript and at international scientific 
      conferences. Results will inform quality improvement strategies, replication of 
      identified good practices, potential policy changes, and future research. 
      PROSPERO REGISTRATION NUMBER: CRD42016040053.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Mburu, Gitau
AU  - Mburu G
AUID- ORCID: 0000-0002-5812-0529
AD  - Centre for Global Health Policy, University of Sussex, Brighton, East Sussex, UK 
      g.mburu@sussex.ac.uk.
AD  - Division of Health Research, Lancaster University, Lancaster, UK.
FAU - Igbinedion, Ewemade
AU  - Igbinedion E
AD  - Department of Community Health, Igbinedion University Teaching Hospital, Okada, 
      Nigeria.
FAU - Lim, Sin How
AU  - Lim SH
AD  - Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala 
      Lumpur, Malaysia.
FAU - Paing, Aung Zayar
AU  - Paing AZ
AD  - Programs Department, Alliance Myanmar, Yangon, Myanmar.
FAU - Yi, Siyan
AU  - Yi S
AD  - Center for Global Health Research, Touro University California, Vallejo, 
      California, USA.
AD  - Saw Swee Hock School of Public Health, National University Singapore, Singapore, 
      Singapore.
AD  - Center for Population Health Research, KHANA, Phnom Penh, Cambodia.
FAU - Elbe, Stefan
AU  - Elbe S
AD  - Centre for Global Health Policy, University of Sussex, Brighton, East Sussex, UK.
FAU - Mwai, Grace W
AU  - Mwai GW
AD  - Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
LA  - eng
PT  - Journal Article
DEP - 20200108
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Costs and Cost Analysis
MH  - Delivery of Health Care/*methods
MH  - Developing Countries
MH  - *HIV
MH  - HIV Infections/economics/epidemiology/*therapy
MH  - Humans
MH  - Private Sector/*economics
MH  - *Quality Improvement
MH  - Systematic Reviews as Topic
PMC - PMC6955520
OTO - NOTNLM
OT  - ART
OT  - HIV
OT  - low-income and middle-income countries
OT  - private sector
OT  - treatment
COIS- Competing interests: None declared.
EDAT- 2020/01/11 06:00
MHDA- 2021/02/10 06:00
PMCR- 2020/01/08
CRDT- 2020/01/11 06:00
PHST- 2020/01/11 06:00 [entrez]
PHST- 2020/01/11 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/01/08 00:00 [pmc-release]
AID - bmjopen-2019-031844 [pii]
AID - 10.1136/bmjopen-2019-031844 [doi]
PST - epublish
SO  - BMJ Open. 2020 Jan 8;10(1):e031844. doi: 10.1136/bmjopen-2019-031844.