PMID- 31919513
OWN - NLM
STAT- MEDLINE
DCOM- 20201124
LR  - 20201124
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 105
IP  - 3
DP  - 2020 Mar 1
TI  - The Relationship of Gastrinoma in MEN 1 to Helicobacter pylori infection.
LID - dgaa004 [pii]
LID - 10.1210/clinem/dgaa004 [doi]
AB  - CONTEXT: Helicobacter pylori and Multiple Endocrine Neoplasia Type 1 (MEN 1) are 
      risk factors for hypergastrinemia. Gastrin-secreting neoplasms of the foregut 
      mucosa are both a source of, and potentially stimulated by, hypergastrinemia. 
      OBJECTIVE: To determine the relationship between H pylori exposure and the 
      prevalence and severity of hypergastrinemia in patients with MEN 1. DESIGN, 
      SETTING & PATIENTS: Cross-sectional analysis of patients with a common MEN1 gene 
      mutation managed at a tertiary referral hospital that underwent fasting serum 
      gastrin and H pylori serum IgG measurement. INTERVENTION: H pylori IgG and serum 
      gastrin concentration, determined via immunoassay. MAIN OUTCOME MEASURES: The 
      prevalence and severity of hypergastrinemia and its relationship to past H pylori 
      exposure. RESULTS: Thirty-four of 95 (36%) patients were H pylori IgG 
      seropositive. H pylori seropositive patients were significantly more likely to 
      exhibit hypergastrinemia compared with seronegative patients (relative risk [RR] 
      1.72, P = .023). H pylori exposure also predicted severe hypergastrinemia (RR 
      3.52, P = .026 and RR 9.37, P = .031 for patients with gastrin >/= x4 and >/= x8 the 
      upper limit of normal [ULN], respectively). Gastrin concentrations >/= x10 ULN 
      occurred exclusively in H pylori seropositive patients (0/61 vs 6/34, P = .001). 
      Serum gastrin and alpha subunit were positively associated in H pylori-exposed 
      (beta = 0.69, P = .001), but not in H pylori-unexposed patients. CONCLUSION: Past H 
      pylori exposure was associated with increased prevalence and severity of 
      hypergastrinemia in MEN 1 patients. Past H pylori-related hypergastrinemia may 
      contribute to the pathogenesis of ongoing gastrin hypersecretion by susceptible 
      foregut neuroendocrine tissues.
CI  - (c) Endocrine Society 2020. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Endall, Ryan
AU  - Endall R
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital.
FAU - Thompson, Michael
AU  - Thompson M
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital.
AD  - School of Medicine, University of Tasmania.
FAU - Parameswaran, Venkat
AU  - Parameswaran V
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital.
AD  - School of Medicine, University of Tasmania.
FAU - Burgess, John
AU  - Burgess J
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital.
AD  - School of Medicine, University of Tasmania.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Gastrins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gastrinoma/blood/complications/*epidemiology/pathology
MH  - Gastrins/blood
MH  - Helicobacter Infections/complications/*epidemiology
MH  - *Helicobacter pylori/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/complications/*epidemiology/pathology
MH  - Pancreatic Neoplasms/blood/complications/*epidemiology/pathology
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Tasmania/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - MEN 1
OT  - gastrin
OT  - gastrinoma
OT  - multiple endocrine neoplasia type 1
EDAT- 2020/01/11 06:00
MHDA- 2020/11/25 06:00
CRDT- 2020/01/11 06:00
PHST- 2019/10/20 00:00 [received]
PHST- 2020/01/09 00:00 [accepted]
PHST- 2020/01/11 06:00 [pubmed]
PHST- 2020/11/25 06:00 [medline]
PHST- 2020/01/11 06:00 [entrez]
AID - 5699748 [pii]
AID - 10.1210/clinem/dgaa004 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgaa004. doi: 10.1210/clinem/dgaa004.