PMID- 3192038
OWN - NLM
STAT- MEDLINE
DCOM- 19881227
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 37
IP  - 12
DP  - 1988 Dec
TI  - Renal response to restricted protein intake in diabetic nephropathy.
PG  - 1641-6
AB  - Proteinuria in diabetes is associated with progressive glomerular damage. We 
      studied the effects of 3-wk dietary protein restriction on proteinuria and renal 
      function in 10 insulin-dependent diabetic men with diabetic nephropathy. Patients 
      were randomly assigned by a crossover design to 40-g low-protein diet (LPD) or 
      usual-protein diet (UPD). Glomerular filtration rate and renal plasma flow were 
      measured by inulin and p-aminohippurate clearance at the end of each period under 
      conditions of sustained euglycemia. Total calorie intake, body weight, serum 
      albumin and total protein concentrations, hematocrit, blood pressure, and glucose 
      control were similar during the two diets. Achieved protein intake was 46 +/- 3 
      g/day during LPD and 81 +/- 4 g/day during UPD (P less than .001). Urinary urea 
      appearance and plasma urea were significantly lower on LPD. Median total urinary 
      protein was reduced from 3.9 g/day (range 0.5-12.3) on UPD to 2.4 (range 0.2-9.0) 
      on LPD (P less than .006), and there was a significant fall in the median 
      fractional clearance of albumin from 2.0 x 10(-4) (range 0.1-90.9) on UPD to 1.0 
      x 10(-4) (range 0.1-51.4) on LPD and IgG from 2.1 x 10(-5) (range 0.2-238) to 1.5 
      x 10(-5) (range 0.1-77) (P less than .006 and P less than .02, respectively). The 
      reabsorption rate of beta 2-microglobulin was similar on the two diets and 
      glomerular filtration rate, renal plasma flow, and filtration fraction remained 
      unchanged. Thus, short-term dietary protein restriction reduces diabetic 
      proteinuria independently of blood glucose or systemic blood pressure changes by 
      improving glomerular permselectivity.
FAU - Bending, J J
AU  - Bending JJ
AD  - Division of Medicine, United Medical School, London.
FAU - Dodds, R A
AU  - Dodds RA
FAU - Keen, H
AU  - Keen H
FAU - Viberti, G C
AU  - Viberti GC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Body Weight
MH  - Diabetic Nephropathies/*physiopathology
MH  - Dietary Proteins/*administration & dosage
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Proteinuria/physiopathology
MH  - Renal Circulation
MH  - Urodynamics
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 10.2337/diab.37.12.1641 [doi]
PST - ppublish
SO  - Diabetes. 1988 Dec;37(12):1641-6. doi: 10.2337/diab.37.12.1641.