PMID- 31920501
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 13
DP  - 2019
TI  - Increased Activation of Default Mode Network in Early Parkinson's With Excessive 
      Daytime Sleepiness.
PG  - 1334
LID - 10.3389/fnins.2019.01334 [doi]
LID - 1334
AB  - BACKGROUND AND OBJECTIVES: The underlying neuropathology of excessive daytime 
      sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to 
      investigate neural network changes that underlie EDS in PD. METHODS: Early PD 
      patients comprising eighty-one patients without EDS (EDS-) and seventeen patients 
      with EDS (EDS+) received a resting state functional MRI scan and the Epworth 
      Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), 
      motor and basal ganglia networks were compared between the EDS+ and EDS- groups. 
      Correlations between network connectivity and the severity of EDS were 
      investigated through linear regression. RESULTS: EDS+ patients displayed a trend 
      of increased network connectivity of the posterior DMN (pDMN). A significant 
      positive correlation was found between connectivity of the ventromedial 
      prefrontal cortex in the pDMN and ESS. CONCLUSION: EDS+ patients are likely to 
      display increased activation in the DMN, suggesting neural compensation in early 
      PD or impaired attentiveness due to mechanisms such as mind-wandering.
CI  - Copyright (c) 2019 Ooi, Wen, Ng, Chia, Chew, Lee, Xu, Hartono, Tan, Chan and Tan.
FAU - Ooi, Leon Qi Rong
AU  - Ooi LQR
AD  - National Neuroscience Institute, Singapore, Singapore.
FAU - Wen, Ming-Ching
AU  - Wen MC
AD  - National Neuroscience Institute, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
FAU - Ng, Samuel Yong-Ern
AU  - Ng SY
AD  - National Neuroscience Institute, Singapore, Singapore.
FAU - Chia, Nicole Shuang-Yu
AU  - Chia NS
AD  - National Neuroscience Institute, Singapore, Singapore.
FAU - Chew, Isabel Hui Min
AU  - Chew IHM
AD  - Singapore General Hospital, Singapore, Singapore.
FAU - Lee, Weiling
AU  - Lee W
AD  - Singapore General Hospital, Singapore, Singapore.
FAU - Xu, Zheyu
AU  - Xu Z
AD  - National Neuroscience Institute, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
FAU - Hartono, Septian
AU  - Hartono S
AD  - National Neuroscience Institute, Singapore, Singapore.
FAU - Tan, Eng King
AU  - Tan EK
AD  - National Neuroscience Institute, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
FAU - Chan, Ling Ling
AU  - Chan LL
AD  - Duke-NUS Medical School, Singapore, Singapore.
AD  - Singapore General Hospital, Singapore, Singapore.
FAU - Tan, Louis Chew-Seng
AU  - Tan LC
AD  - National Neuroscience Institute, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20191212
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
EIN - Front Neurosci. 2020 May 12;14:426. PMID: 32528240
PMC - PMC6920242
OTO - NOTNLM
OT  - Parkinson's disease
OT  - excessive daytime sleepiness
OT  - independent component analyses
OT  - neural network
OT  - resting state fMRI
EDAT- 2020/01/11 06:00
MHDA- 2020/01/11 06:01
PMCR- 2019/01/01
CRDT- 2020/01/11 06:00
PHST- 2019/09/17 00:00 [received]
PHST- 2019/11/27 00:00 [accepted]
PHST- 2020/01/11 06:00 [entrez]
PHST- 2020/01/11 06:00 [pubmed]
PHST- 2020/01/11 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2019.01334 [doi]
PST - epublish
SO  - Front Neurosci. 2019 Dec 12;13:1334. doi: 10.3389/fnins.2019.01334. eCollection 
      2019.