PMID- 31921371
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1813-7253 (Print)
IS  - 1861-6909 (Electronic)
IS  - 1813-7253 (Linking)
VI  - 17
DP  - 2020
TI  - Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, 
      aerobic fitness, cognitive capacity and quality of life among seniors with mild 
      to moderate Alzheimer's disease: a randomized controlled trial.
PG  - 2
LID - 10.1186/s11556-019-0234-1 [doi]
LID - 2
AB  - BACKGROUND: Evidence suggests that aerobic-type training confers physical 
      benefits and appears to contribute positively to brain health. This study aims to 
      compare the effect of 9-weeks continuous (CAT) to interval aerobic training (IAT) 
      on brain derived neurotrophic factor (BDNF) plasma level, aerobic fitness, 
      cognitive performance, and quality of life among senior with Alzheimer's disease 
      (AD). METHODS: 52 participants were randomly allocated into three groups (CAT 
      n = 14; IAT n = 17; and Controls n = 21). CAT and IAT consisted of 18 sessions of 
      30-min cycling, twice a week, over 9 weeks. During the same period, controls were 
      engaged in interactive information sessions. Plasma BDNF level; aerobic fitness 
      parameters (Metabolic equivalent task - METs; Maximal Tolerated Power - MTP); 
      functional capacities (6-Minute Walk Test - 6MWT); cognitive performance (Mini 
      Mental State Examination; Rey auditory verbal learning test; and digit span test) 
      and quality of life (Quality Of Life of Alzheimer's Disease scale - QoL-AD) were 
      measured in all participants at baseline and 9 weeks later. A third plasma BDNF 
      level was quantified following a 4 weeks detraining. RESULTS: No significant 
      change was measured in terms of plasma BDNF level and cognitive performance after 
      interventions, in all groups compared to baseline. After 9 weeks, CAT and IAT 
      significantly improved aerobic fitness parameters compared to controls (METs: 
      + 0.6 and + 1.0 vs. + 0.4; MTP: + 16 watts and + 20 watts vs. + 10 watts; and 
      functional capacities (6MWT: + 22 m and + 31 m vs. -40 m). Compared to controls, 
      QoL-AD after CAT was improved (+ 2 points; p = 0.02). CONCLUSIONS: Neither 
      aerobic exercise modalities significantly modified plasma BDNF levels and 
      cognitive performances. CAT and IAT enhanced aerobic fitness and functional 
      capacities in AD patients and CAT their QoL. TRIAL REGISTRATION: 
      ClinicalTrials.gov website (NCT02968875); registration date: 7 September 2016. 
      "Retrospectively registered".
CI  - (c) The Author(s) 2020.
FAU - Enette, Lievyn
AU  - Enette L
AUID- ORCID: 0000-0002-1752-7269
AD  - 1Research Laboratory Mitochondria, Oxidative stress and muscle resistance (MSP, 
      EA-3072), Department of Physiology, Faculty of Medicine, Strasbourg University, 
      Residence La Yole, bat. B L'Etang Z'abricot, 97200 Strasbourg, France. ISNI: 0000 
      0001 2157 9291. GRID: grid.11843.3f
FAU - Vogel, Thomas
AU  - Vogel T
AD  - 1Research Laboratory Mitochondria, Oxidative stress and muscle resistance (MSP, 
      EA-3072), Department of Physiology, Faculty of Medicine, Strasbourg University, 
      Residence La Yole, bat. B L'Etang Z'abricot, 97200 Strasbourg, France. ISNI: 0000 
      0001 2157 9291. GRID: grid.11843.3f
AD  - 2Department of geriatric, University Hospital, Strasbourg, France. ISNI: 0000 
      0001 2177 138X. GRID: grid.412220.7
FAU - Merle, Sylvie
AU  - Merle S
AD  - Methodology and biostatistics Unit (DRCI), University Hospital Centre of 
      Martinique, Fort de France, France.
FAU - Valard-Guiguet, Anna-Gaelle
AU  - Valard-Guiguet AG
AD  - The Caribbean reference center for rare neuromuscular and neurologic diseases 
      (CeRCa), University Hospital Centre of Martinique, Fort de France, France.
FAU - Ozier-Lafontaine, Nathalie
AU  - Ozier-Lafontaine N
AD  - Department of Functional Exploration and Non-Invasive Cardiology, University 
      Hospital Centre of Martinique, Fort de France, France.
FAU - Neviere, Remi
AU  - Neviere R
AD  - Department of cardiology, University Hospital Centre of Martinique, Fort de 
      France, France.
FAU - Leuly-Joncart, Claudia
AU  - Leuly-Joncart C
AD  - Department of Geriatric and Gerontology, University Hospital Centre of 
      Martinique, Fort de France, France.
FAU - Fanon, Jean Luc
AU  - Fanon JL
AD  - Department of Geriatric and Gerontology, University Hospital Centre of 
      Martinique, Fort de France, France.
FAU - Lang, Pierre Olivier
AU  - Lang PO
AD  - Clinic of Montchoisi, Lausanne, Switzerland.
LA  - eng
SI  - ClinicalTrials.gov/NCT02968875
PT  - Journal Article
DEP - 20200106
PL  - Germany
TA  - Eur Rev Aging Phys Act
JT  - European review of aging and physical activity : official journal of the European 
      Group for Research into Elderly and Physical Activity
JID - 101284836
PMC - PMC6945614
OTO - NOTNLM
OT  - Aerobic exercise, aerobic fitness, BDNF, Alzheimer's disease, cognitive 
      performance, older adults
COIS- Competing interestsNone of the above listed authors has any conflicts of 
      interests to declare for the present manuscript.
EDAT- 2020/01/11 06:00
MHDA- 2020/01/11 06:01
PMCR- 2020/01/06
CRDT- 2020/01/11 06:00
PHST- 2019/03/25 00:00 [received]
PHST- 2019/12/29 00:00 [accepted]
PHST- 2020/01/11 06:00 [entrez]
PHST- 2020/01/11 06:00 [pubmed]
PHST- 2020/01/11 06:01 [medline]
PHST- 2020/01/06 00:00 [pmc-release]
AID - 234 [pii]
AID - 10.1186/s11556-019-0234-1 [doi]
PST - epublish
SO  - Eur Rev Aging Phys Act. 2020 Jan 6;17:2. doi: 10.1186/s11556-019-0234-1. 
      eCollection 2020.