PMID- 31922056
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2468-0249 (Electronic)
IS  - 2468-0249 (Linking)
VI  - 5
IP  - 1
DP  - 2020 Jan
TI  - Relapse in Anti-Neutrophil Cytoplasm Antibody (ANCA)-Associated Vasculitis.
PG  - 7-12
LID - 10.1016/j.ekir.2019.10.005 [doi]
AB  - Clinical relapses are common in anti-neutrophil cytoplasm antibody 
      (ANCA)-associated vasculitis, necessitating repeated treatment with 
      immunosuppressive therapy, and increasing the risks of severe adverse events. 
      Better understanding the basis of relapse would help stratify patients, testing 
      the notion that more treatment may prevent development of relapse, whereas in 
      those at low risk of disease flares, treatment minimization may be appropriate, 
      reducing risks of adverse events, most notably infectious complications and drug 
      toxicity. However, relapse can only occur following remission, and although 
      defining clinical remission may seem straightforward, there is evidence in many 
      remission patients of persistent inflammatory and immunological activity, at 
      levels above those found in healthy individuals. This suggests that we may not 
      truly be achieving disease remission in many patients and these persistent 
      responses may set the patient up for subsequent disease flares. Understanding the 
      underlying pathophysiological basis of disease activity and remission is 
      paramount to help define better biomarkers of relapse, which should positively 
      affect adverse events and patient outcomes.
CI  - (c) 2019 International Society of Nephrology. Published by Elsevier Inc.
FAU - Salama, Alan D
AU  - Salama AD
AD  - UCL Department of Renal Medicine, Royal Free Hospital, London, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191024
PL  - United States
TA  - Kidney Int Rep
JT  - Kidney international reports
JID - 101684752
PMC - PMC6943777
OTO - NOTNLM
OT  - ANCA
OT  - relapse
OT  - vasculitis
EDAT- 2020/01/11 06:00
MHDA- 2020/01/11 06:01
PMCR- 2019/10/24
CRDT- 2020/01/11 06:00
PHST- 2019/08/10 00:00 [received]
PHST- 2019/10/13 00:00 [revised]
PHST- 2019/10/15 00:00 [accepted]
PHST- 2020/01/11 06:00 [entrez]
PHST- 2020/01/11 06:00 [pubmed]
PHST- 2020/01/11 06:01 [medline]
PHST- 2019/10/24 00:00 [pmc-release]
AID - S2468-0249(19)31520-7 [pii]
AID - 10.1016/j.ekir.2019.10.005 [doi]
PST - epublish
SO  - Kidney Int Rep. 2019 Oct 24;5(1):7-12. doi: 10.1016/j.ekir.2019.10.005. 
      eCollection 2020 Jan.