PMID- 31924200
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 18
IP  - 1
DP  - 2020 Jan 10
TI  - The potential therapeutic effects of the gut microbiome manipulation by synbiotic 
      containing-Lactobacillus plantarum on neuropsychological performance of diabetic 
      rats.
PG  - 18
LID - 10.1186/s12967-019-02169-y [doi]
LID - 18
AB  - BACKGROUND: The manipulation of gut microbiota as a target has been suggested to 
      reduce the risks for a number of diseases such as type 2 diabetes mellitus 
      (T2DM). Conversely, T2DM is associated with complications such as gut and brain 
      disorders. Furthermore, the impact of probiotics and prebiotics to improve T2DM 
      complications are reported. Thus, the present study seeks to investigate the 
      therapeutic and neuropsychological effects of L. plantarum and inulin in diabetic 
      rats. METHODS: Throughout the investigation, L. plantarum, inulin or their 
      combination (synbiotic) was administered to diabetic rats. in the end, fecal 
      samples were collected to evaluate the gut microbial composition. Then behavioral 
      tests were conducted. Subsequently, the obtainment of the prefrontal cortex (PFC) 
      and hippocampal samples. RESULTS: Our data demonstrated that administration of L. 
      plantarum and inulin could improve gut dysbiosis and oxidative stress status. In 
      addition, it could ameliorate serotonin and BDNF/TrkB signaling pathway. Notably, 
      a strong correlation between the gut microbiota changes and cognition responses 
      was observed. Interestingly, synbiotics intake exploited a rather powerful effect 
      on oxidative stress markers. CONCLUSION: The findings confirm that there is a 
      beneficial therapeutic potential of supplements, especially symbiotic. Moreover, 
      neuropsychological improvement associated with balanced gut microbiome.
FAU - Morshedi, Mohammad
AU  - Morshedi M
AUID- ORCID: 0000-0002-6829-5189
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Saghafi-Asl, Maryam
AU  - Saghafi-Asl M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. saghafiaslm@gmail.com.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. saghafiaslm@gmail.com.
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. saghafiaslm@gmail.com.
FAU - Hosseinifard, Elaheh-Sadat
AU  - Hosseinifard ES
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. Elaheh.hosseinifard@gmail.com.
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. Elaheh.hosseinifard@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200110
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Prebiotics)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Experimental
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - *Gastrointestinal Microbiome
MH  - *Lactobacillus plantarum
MH  - Male
MH  - Prebiotics
MH  - *Probiotics/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - *Synbiotics
PMC - PMC6953298
OTO - NOTNLM
OT  - Behavior
OT  - Diabetes
OT  - Dysbiosis
OT  - Gut-brain axis
OT  - Microbiota
OT  - Probiotic
COIS- The authors declare that they have no competing interests.
EDAT- 2020/01/12 06:00
MHDA- 2021/05/11 06:00
PMCR- 2020/01/10
CRDT- 2020/01/12 06:00
PHST- 2019/09/26 00:00 [received]
PHST- 2019/12/05 00:00 [accepted]
PHST- 2020/01/12 06:00 [entrez]
PHST- 2020/01/12 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2020/01/10 00:00 [pmc-release]
AID - 10.1186/s12967-019-02169-y [pii]
AID - 2169 [pii]
AID - 10.1186/s12967-019-02169-y [doi]
PST - epublish
SO  - J Transl Med. 2020 Jan 10;18(1):18. doi: 10.1186/s12967-019-02169-y.