PMID- 31925906
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20240328
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 19
IP  - 5
DP  - 2020 Jun
TI  - Differential genetic risk for methamphetamine intake confers differential 
      sensitivity to the temperature-altering effects of other addictive drugs.
PG  - e12640
LID - 10.1111/gbb.12640 [doi]
AB  - Mice selectively bred for high methamphetamine (MA) drinking (MAHDR), compared 
      with mice bred for low MA drinking (MALDR), exhibit greater sensitivity to MA 
      reward and insensitivity to aversive and hypothermic effects of MA. Previous work 
      identified the trace amine-associated receptor 1 gene (Taar1) as a quantitative 
      trait gene for MA intake that also impacts thermal response to MA. All MAHDR mice 
      are homozygous for the mutant Taar1 (m1J) allele, whereas all MALDR mice possess 
      at least one copy of the reference Taar1 (+) allele. To determine if their 
      differential sensitivity to MA-induced hypothermia extends to drugs of similar 
      and different classes, we examined sensitivity to the hypothermic effect of the 
      stimulant cocaine, the amphetamine-like substance 
      3,4-methylenedioxymethamphetamine (MDMA), and the opioid morphine in these lines. 
      The lines did not differ in thermal response to cocaine, only MALDR mice 
      exhibited a hypothermic response to MDMA, and MAHDR mice were more sensitive to 
      the hypothermic effect of morphine than MALDR mice. We speculated that the 
      mu-opioid receptor gene (Oprm1) impacts morphine response, and genotyped the mice 
      tested for morphine-induced hypothermia. We report genetic linkage between Taar1 
      and Oprm1; MAHDR mice more often inherit the Oprm1 (D2) allele and MALDR mice 
      more often inherit the Oprm1 (B6) allele. Data from a family of recombinant 
      inbred mouse strains support the influence of Oprm1 genotype, but not Taar1 
      genotype, on thermal response to morphine. These results nominate Oprm1 as a 
      genetic risk factor for morphine-induced hypothermia, and provide additional 
      evidence for a connection between drug preference and drug thermal response.
CI  - Published 2020. This article is a U.S. Government work and is in the public 
      domain in the USA.
FAU - Mootz, John R K
AU  - Mootz JRK
AUID- ORCID: 0000-0003-0309-4340
AD  - Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, 
      Oregon Health & Science University, Portland, Oregon.
FAU - Miner, Nicholas B
AU  - Miner NB
AD  - Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, 
      Oregon Health & Science University, Portland, Oregon.
FAU - Phillips, Tamara J
AU  - Phillips TJ
AUID- ORCID: 0000-0002-7350-6323
AD  - Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, 
      Oregon Health & Science University, Portland, Oregon.
AD  - Division of Research, Veterans Affairs Portland Health Care System, Portland, 
      Oregon.
LA  - eng
GR  - T32 DA007262/DA/NIDA NIH HHS/United States
GR  - R01 DA034388/DA/NIDA NIH HHS/United States
GR  - P50 DA018165/DA/NIDA NIH HHS/United States
GR  - R01 DA046081/DA/NIDA NIH HHS/United States
GR  - U01 DA041579/DA/NIDA NIH HHS/United States
GR  - R24 AA020245/AA/NIAAA NIH HHS/United States
GR  - I01 BX002106/BX/BLRD VA/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20200115
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Dopamine Agents)
RN  - 0 (Oprm protein, mouse)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Opioid, mu)
RN  - 44RAL3456C (Methamphetamine)
RN  - 76I7G6D29C (Morphine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - XMC8VP6RI2 (Trace amine-associated receptor 1)
SB  - IM
MH  - Amphetamine-Related Disorders/*genetics/physiopathology
MH  - Analgesics, Opioid/*pharmacology
MH  - Animals
MH  - Cocaine/pharmacology
MH  - Dopamine Agents/*pharmacology
MH  - Female
MH  - Genotype
MH  - Hypothermia/*genetics
MH  - Male
MH  - Methamphetamine/pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Morphine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Receptors, G-Protein-Coupled/*genetics
MH  - Receptors, Opioid, mu/*genetics
MH  - Thermosensing/drug effects/genetics
PMC - PMC7286770
MID - NIHMS1589795
OTO - NOTNLM
OT  - addiction
OT  - methamphetamine
OT  - opioids
OT  - thermal regulation
OT  - trace amine-associated receptor 1
OT  - mu-opioid receptor
EDAT- 2020/01/12 06:00
MHDA- 2021/07/16 06:00
PMCR- 2021/06/01
CRDT- 2020/01/12 06:00
PHST- 2019/11/08 00:00 [received]
PHST- 2020/01/07 00:00 [revised]
PHST- 2020/01/07 00:00 [accepted]
PHST- 2020/01/12 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2020/01/12 06:00 [entrez]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 10.1111/gbb.12640 [doi]
PST - ppublish
SO  - Genes Brain Behav. 2020 Jun;19(5):e12640. doi: 10.1111/gbb.12640. Epub 2020 Jan 
      15.