PMID- 31925910
OWN - NLM
STAT- MEDLINE
DCOM- 20210928
LR  - 20210928
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 108
IP  - 4
DP  - 2020 Apr
TI  - Incorporating silica-coated graphene in bioceramic nanocomposites to 
      simultaneously enhance mechanical and biological performance.
PG  - 1016-1027
LID - 10.1002/jbm.a.36880 [doi]
AB  - The applications of a variety of bioactive ceramics such as hydroxyapatite (HA) 
      in orthopedics are limited by their insufficient mechanical properties, 
      especially poor fracture toughness. Thus, further extending the clinical 
      applications of these materials warrants the enhancement of their mechanical 
      properties. Although the reinforcement of ceramics by 2D nanomaterials has been 
      well recognized, integrated structural, mechanical, and functional considerations 
      have been neglected in the design and synthesis of such composite materials. 
      Herein, we report the first use of silica-coated reduced graphene oxide (S-rGO) 
      hybrid nanosheets to create bioceramic-based composites with simultaneously 
      enhanced mechanical and biological properties. In the representative HA-based 
      bioceramic systems prepared by spark plasma sintering, S-rGO incorporation was 
      found to be more effective for increasing the Young's modulus, hardness, and 
      fracture toughness than the incorporation of uncoated reduced GO (rGO). 
      Furthermore, when assessed with osteoblast-like MG-63 cells, such novel materials 
      led to faster cell proliferation and higher cell viability and alkaline 
      phosphatase activity than are generally observed with pure HA; additionally, 
      cells demonstrate stronger affinity to S-rGO/HA than to rGO/HA composites. The 
      S-rGO/bioceramic composites are therefore promising for applications in 
      orthopedic tissue engineering, and this research provides valuable insights into 
      the fabrication of silica-coated hybrid nanosheet-reinforced ceramics.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Li, Zhong
AU  - Li Z
AD  - School of Mechanical & Aerospace Engineering, Nanyang Technological University, 
      Singapore.
AD  - Center for Cellular and Molecular Engineering (CCME), Department of Orthopaedic 
      Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
FAU - Zhu, Wenyu
AU  - Zhu W
AD  - School of Civil & Environmental Engineering, Nanyang Technological University, 
      Singapore.
FAU - Bi, Shuguang
AU  - Bi S
AD  - School of Mechanical & Aerospace Engineering, Nanyang Technological University, 
      Singapore.
AD  - School of Materials Science & Engineering, Nanyang Technological University, 
      Singapore.
FAU - Li, Ruitao
AU  - Li R
AD  - School of Mechanical & Aerospace Engineering, Nanyang Technological University, 
      Singapore.
AD  - School of Materials Science & Engineering, Nanyang Technological University, 
      Singapore.
FAU - Hu, Huanlong
AU  - Hu H
AD  - School of Mechanical & Aerospace Engineering, Nanyang Technological University, 
      Singapore.
FAU - Lin, Hang
AU  - Lin H
AD  - Center for Cellular and Molecular Engineering (CCME), Department of Orthopaedic 
      Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
FAU - Tuan, Rocky S
AU  - Tuan RS
AD  - Center for Cellular and Molecular Engineering (CCME), Department of Orthopaedic 
      Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
FAU - Khor, Khiam Aik
AU  - Khor KA
AD  - School of Mechanical & Aerospace Engineering, Nanyang Technological University, 
      Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200120
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Powders)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 7782-42-5 (Graphite)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Cell Line, Tumor
MH  - Ceramics/*chemistry
MH  - Culture Media, Conditioned/pharmacology
MH  - Durapatite/chemistry
MH  - Graphite/*chemistry
MH  - Humans
MH  - Nanocomposites/*chemistry
MH  - Nanotubes/chemistry/ultrastructure
MH  - Powders
MH  - Silicon Dioxide/*chemistry
MH  - Thermogravimetry
OTO - NOTNLM
OT  - cytocompatibility
OT  - fracture toughness
OT  - hybrid 2D nanomaterial
OT  - hydroxyapatite
OT  - spark plasma sintering
EDAT- 2020/01/12 06:00
MHDA- 2021/09/29 06:00
CRDT- 2020/01/12 06:00
PHST- 2019/01/13 00:00 [received]
PHST- 2019/12/28 00:00 [revised]
PHST- 2019/12/31 00:00 [accepted]
PHST- 2020/01/12 06:00 [pubmed]
PHST- 2021/09/29 06:00 [medline]
PHST- 2020/01/12 06:00 [entrez]
AID - 10.1002/jbm.a.36880 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2020 Apr;108(4):1016-1027. doi: 10.1002/jbm.a.36880. Epub 
      2020 Jan 20.