PMID- 31926908
OWN - NLM
STAT- MEDLINE
DCOM- 20210727
LR  - 20210727
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1732
DP  - 2020 Apr 1
TI  - Effect of the brain-derived neurotrophic factor gene Val66Met polymorphism on 
      sensory-motor integration during a complex motor learning exercise.
PG  - 146652
LID - S0006-8993(20)30008-1 [pii]
LID - 10.1016/j.brainres.2020.146652 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism may cause 
      impairment in short-term motor learning by reducing activity-dependent BDNF 
      expression, which causes alterations in synaptic plasticity by changing 
      glutamatergic and GABAergic synaptic transmissions. Sensory-motor integration 
      (SMI) plays an important role in motor learning. In this study, we investigated 
      the role of this polymorphism on SMI during a complex motor learning practice. 
      Forty-three healthy participants performed standardized 5-day basketball shooting 
      exercises under supervision. Electrophysiologic SMI studies were performed before 
      the first day exercise (T0) and after the first and fifth day exercises (T1 and 
      T2, respectively). SMI was studied using electrical median nerve stimulation at 
      the wrist, followed by transcranial magnetic stimulation (TMS) of the 
      contralateral motor cortex with various inter-stimulus intervals (ISIs). 
      Recordings were made from the thenar and forearm flexor muscles. Participants 
      were divided into two groups according to their BDNF genotype. Group 1 consisted 
      of 26 subjects with the Val66Val genotype and group 2 included 17 subjects with 
      the BDNF Met allele. Group 2 had a lower increase in basketball scores at day 5. 
      Moreover, they had higher afferent facilitation for the responses recorded from 
      both thenar and forearm flexor muscles at T1, but these changes could not be 
      maintained until T2. This non-persistent early hyper-responsivity of the 
      sensory-motor cortex in subjects with the BDNF Met allele might be explained by a 
      transient upsurge of cortical excitability to compensate the insufficient 
      cortical plasticity during motor learning, which could be considered as a sign of 
      lower performance in motor skill learning.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Deveci, Sule Sule
AU  - Deveci SS
AD  - Departments of Neurology and Clinical Neurophysiology, Istanbul University, 
      Istanbul Faculty of Medicine, Topkapi Mahallesi, Turgut Ozal Millet Cd., 34093 
      Fatih, Istanbul, Turkey. Electronic address: suledeveci75@gmail.com.
FAU - Matur, Zeliha
AU  - Matur Z
AD  - Departments of Neurology and Clinical Neurophysiology, Istanbul University, 
      Istanbul Faculty of Medicine, Topkapi Mahallesi, Turgut Ozal Millet Cd., 34093 
      Fatih, Istanbul, Turkey; Department of Neurology, Demiroglu (Demiroglu) Bilim 
      University, Medical Faculty, Esentepe Mahallesi, Buyukdere Cd. No:120, 34394 
      Sisli, Istanbul, Turkey. Electronic address: zeliha.matur@demiroglu.bilim.edu.tr.
FAU - Kesim, Yesim Yesim
AU  - Kesim YY
AD  - Department of Genetics, Istanbul University, Aziz Sancar Institute of 
      Experimental Medicine, Topkapi Mahallesi, Vakif Gureba Cd., 34093 Sehremini, 
      Fatih, Istanbul, Turkey.
FAU - Senturk Senturk, Gokce Gokce
AU  - Senturk Senturk GG
AD  - Departments of Neurology and Clinical Neurophysiology, Istanbul University, 
      Istanbul Faculty of Medicine, Topkapi Mahallesi, Turgut Ozal Millet Cd., 34093 
      Fatih, Istanbul, Turkey.
FAU - Sargin-Kurt, Gulcan Gulcan
AU  - Sargin-Kurt GG
AD  - Departments of Neurology and Clinical Neurophysiology, Istanbul University, 
      Istanbul Faculty of Medicine, Topkapi Mahallesi, Turgut Ozal Millet Cd., 34093 
      Fatih, Istanbul, Turkey.
FAU - Ugur Ugur, Sibel Aylin
AU  - Ugur Ugur SA
AD  - Department of Genetics, Istanbul University, Aziz Sancar Institute of 
      Experimental Medicine, Topkapi Mahallesi, Vakif Gureba Cd., 34093 Sehremini, 
      Fatih, Istanbul, Turkey. Electronic address: sibel.ugur@istanbul.edu.tr.
FAU - Oge Oge, Ali Emre
AU  - Oge Oge AE
AD  - Departments of Neurology and Clinical Neurophysiology, Istanbul University, 
      Istanbul Faculty of Medicine, Topkapi Mahallesi, Turgut Ozal Millet Cd., 34093 
      Fatih, Istanbul, Turkey. Electronic address: aemreoge@istanbul.edu.tr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200109
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Athletic Performance
MH  - Basketball/physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Learning/*physiology
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Psychomotor Performance/*physiology
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF Met allele
OT  - Brain-derived neurotrophic factor
OT  - Motor skill learning
OT  - Sensory-motor integration
OT  - Transcranial magnetic stimulation
EDAT- 2020/01/14 06:00
MHDA- 2021/07/28 06:00
CRDT- 2020/01/14 06:00
PHST- 2019/09/19 00:00 [received]
PHST- 2019/12/15 00:00 [revised]
PHST- 2020/01/07 00:00 [accepted]
PHST- 2020/01/14 06:00 [pubmed]
PHST- 2021/07/28 06:00 [medline]
PHST- 2020/01/14 06:00 [entrez]
AID - S0006-8993(20)30008-1 [pii]
AID - 10.1016/j.brainres.2020.146652 [doi]
PST - ppublish
SO  - Brain Res. 2020 Apr 1;1732:146652. doi: 10.1016/j.brainres.2020.146652. Epub 2020 
      Jan 9.