PMID- 31926947
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210520
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 78
DP  - 2020 Mar-Apr
TI  - Bisphenol A (BPA) induces progesterone receptor expression in an estrogen 
      receptor alpha-dependent manner in perinatal brain.
PG  - 106864
LID - S0892-0362(19)30093-5 [pii]
LID - 10.1016/j.ntt.2020.106864 [doi]
AB  - Bisphenol A (BPA) is a xenoestrogen that is prevalent in the environment of 
      industrialized nations due its use in the production of many plastic household 
      items. Virtually all adults in the U.S. have detectable levels of BPA in urine 
      and it can be measured in fetal serum and in breastmilk, making developmental 
      exposure a particular concern. The present study utilizes a progesterone receptor 
      (PR) expression bioassay to assess the estrogen receptor alpha (ERalpha)-dependent 
      effects of BPA in fetal rodent brain following maternal exposure. Maternal 
      ingestion of 10 mug/kg/day, but not 50 mug/kg/day, BPA from gestational day 14-22 
      significantly increased levels of PR immunoreactivity (PRir) in the medial 
      preoptic nucleus (MPN) of female offspring. PR expression in the perinatal MPN is 
      highly dependent on the activation of ERalpha, but not ERbeta, by estrogens. Indeed, 
      injections of BPA (5 mug/kg) to neonates from postnatal day 2-4 (P2-4) 
      significantly increased PR expression in the MPN of postnatal day 5 females 
      compared to the MPN of females administered the oil vehicle. However, 
      pretreatment with the ER antagonist, ICI 182,780 from P1-4 significantly 
      attenuated the effects of BPA on PR expression, indicating an ERalpha-dependent 
      mechanism. The present results also demonstrate a non-monotonic effect of BPA on 
      the direct expression of a transcription factor in developing brain.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Fahrenkopf, Allyssa
AU  - Fahrenkopf A
AD  - Department of Psychology & Center for Neuroscience Research, University at 
      Albany, Albany, NY, USA.
FAU - Wagner, Christine K
AU  - Wagner CK
AD  - Department of Psychology & Center for Neuroscience Research, University at 
      Albany, Albany, NY, USA. Electronic address: cwagner@albany.edu.
LA  - eng
GR  - R21 HD091788/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20200109
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 0 (Receptors, Progesterone)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/*toxicity
MH  - Estrogen Receptor alpha/*biosynthesis
MH  - Estrogens, Non-Steroidal/*toxicity
MH  - Female
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Preoptic Area/*drug effects/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, Progesterone/*biosynthesis
PMC - PMC8130848
MID - NIHMS1698526
OTO - NOTNLM
OT  - Bisphenol A
OT  - Development
OT  - Estrogen receptor
OT  - Progesterone receptor
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/01/14 06:00
MHDA- 2021/01/26 06:00
PMCR- 2021/05/18
CRDT- 2020/01/14 06:00
PHST- 2019/07/11 00:00 [received]
PHST- 2019/11/18 00:00 [revised]
PHST- 2020/01/08 00:00 [accepted]
PHST- 2020/01/14 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/01/14 06:00 [entrez]
PHST- 2021/05/18 00:00 [pmc-release]
AID - S0892-0362(19)30093-5 [pii]
AID - 10.1016/j.ntt.2020.106864 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2020 Mar-Apr;78:106864. doi: 10.1016/j.ntt.2020.106864. 
      Epub 2020 Jan 9.