PMID- 31927718
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20210122
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 40
IP  - 6
DP  - 2020 Aug
TI  - Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain 
      Tissue of Obsessive-Compulsive Disorder Rats.
PG  - 991-997
LID - 10.1007/s10571-020-00788-4 [doi]
AB  - The present study aims to discuss the effect of escitalopram in glial cell 
      line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) 
      levels, and 5-Hydroxytryptamine (5-HT) in obsessive-compulsive disorder rats. A 
      total of 42 rats were divided into three groups randomly: control group (n = 14), 
      model group (n = 14) (obsessive-compulsive disorder group), and escitalopram 
      group (n = 14) (model + obsessive-compulsive disorder group + escitalopram 
      treatment). The open-field method was used to test the rat behavior, 
      enzyme-linked immunosorbent assay (ELISA) was used to determine the serum GDNF 
      and BDNF levels. In addition, Western blot was used to determine the brain tissue 
      protein levels of GDNF and BDNF and high-performance liquid 
      chromatography + electrochemistry method to determine the 5-HT level of brain 
      tissue. Visiting place was changed, rotational frequency and fixed duration 
      enhanced in escitalopram group compared to model group (P < 0.05). Besides, GDNF 
      and BDNF levels of serum and brain tissue were decreased in model group and 
      escitalopram group compared to control group (P < 0.05), while GDNF and BDNF 
      levels of serum and brain tissue were increased in escitalopram group compared to 
      model group (P < 0.05). Moreover, the 5-HT level of brain tissue in escitalopram 
      group was higher than that in model group (P < 0.05). Escitalopram could increase 
      GDNF and BDNF levels and 5-HT content in serum and brain tissue in 
      obsessive-compulsive disorder rats, which contributes to a function on the 
      treatment of obsessive-compulsive disorder.
FAU - Guo, Hui-Rong
AU  - Guo HR
AUID- ORCID: 0000-0002-1167-0443
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 of Jianshe East Road, Erqi District, Zhengzhou, 450052, China. 
      ruirongguo123@163.com.
FAU - Huang, Bai-Ling
AU  - Huang BL
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 of Jianshe East Road, Erqi District, Zhengzhou, 450052, China.
FAU - Wang, Ya-Li
AU  - Wang YL
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 of Jianshe East Road, Erqi District, Zhengzhou, 450052, China.
FAU - Zhang, Yan-Yan
AU  - Zhang YY
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 of Jianshe East Road, Erqi District, Zhengzhou, 450052, China.
FAU - Ma, Quan-Gang
AU  - Ma QG
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 of Jianshe East Road, Erqi District, Zhengzhou, 450052, China.
FAU - Lv, Pei-Pei
AU  - Lv PP
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 of Jianshe East Road, Erqi District, Zhengzhou, 450052, China.
FAU - Ren, Yu-Ming
AU  - Ren YM
AD  - Basic Medical School, Xinxiang Medical University, No.1 Jinsui Avenue, Hongqi 
      District, XinXiang, 453003, China.
LA  - eng
GR  - 172102310578/Science and Technology Department of Henan Province (CN)/
PT  - Journal Article
DEP - 20200111
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Citalopram/*pharmacology
MH  - Glial Cell Line-Derived Neurotrophic Factor/*blood
MH  - Obsessive-Compulsive Disorder/*blood
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Escitalopram
OT  - Glial cell-derived neurotrophic factor
OT  - Obsessive-compulsive disorder
OT  - Serotonin
EDAT- 2020/01/14 06:00
MHDA- 2021/01/23 06:00
CRDT- 2020/01/14 06:00
PHST- 2019/09/20 00:00 [received]
PHST- 2020/01/04 00:00 [accepted]
PHST- 2020/01/14 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
PHST- 2020/01/14 06:00 [entrez]
AID - 10.1007/s10571-020-00788-4 [pii]
AID - 10.1007/s10571-020-00788-4 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2020 Aug;40(6):991-997. doi: 10.1007/s10571-020-00788-4. Epub 
      2020 Jan 11.