PMID- 31928558
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20231111
IS  - 1475-2700 (Electronic)
IS  - 0954-4224 (Print)
IS  - 0954-4224 (Linking)
VI  - 33
IP  - 1
DP  - 2020 Jun
TI  - Expert consensus on low-calorie sweeteners: facts, research gaps and suggested 
      actions.
PG  - 145-154
LID - 10.1017/S0954422419000283 [doi]
AB  - A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 
      where seventeen experts (the panel) discussed three themes identified as key to 
      the science and policy of LCS: (1) weight management and glucose control; (2) 
      consumption, safety and perception; (3) nutrition policy. The aims were to 
      identify the reliable facts on LCS, suggest research gaps and propose future 
      actions. The panel agreed that the safety of LCS is demonstrated by a substantial 
      body of evidence reviewed by regulatory experts and current levels of 
      consumption, even for high users, are within agreed safety margins. However, 
      better risk communication is needed. More emphasis is required on the role of LCS 
      in helping individuals reduce their sugar and energy intake, which is a public 
      health priority. Based on reviews of clinical evidence to date, the panel 
      concluded that LCS can be beneficial for weight management when they are used to 
      replace sugar in products consumed in the diet (without energy substitution). The 
      available evidence suggests no grounds for concerns about adverse effects of LCS 
      on sweet preference, appetite or glucose control; indeed, LCS may improve 
      diabetic control and dietary compliance. Regarding effects on the human gut 
      microbiota, data are limited and do not provide adequate evidence that LCS affect 
      gut health at doses relevant to human use. The panel identified research 
      priorities, including collation of the totality of evidence on LCS and body 
      weight control, monitoring and modelling of LCS intakes, impacts on sugar 
      reduction and diet quality and developing effective communication strategies to 
      foster informed choice. There is also a need to reconcile policy discrepancies 
      between organisations and reduce regulatory hurdles that impede low-energy 
      product development and reformulation.
FAU - Ashwell, Margaret
AU  - Ashwell M
AD  - Ashwell Associates, Ashwell, Hertfordshire, UK.
FAU - Gibson, Sigrid
AU  - Gibson S
AUID- ORCID: 0000-0003-4300-3140
AD  - Sig-Nurture Ltd, Guildford, Surrey, UK.
FAU - Bellisle, France
AU  - Bellisle F
AD  - Nutri Psy Consult, Paris, France.
FAU - Buttriss, Judith
AU  - Buttriss J
AD  - British Nutrition Foundation, London, UK.
FAU - Drewnowski, Adam
AU  - Drewnowski A
AD  - Center for Public Health Nutrition, University of Washington, Seattle, WA, USA.
FAU - Fantino, Marc
AU  - Fantino M
AD  - Fantino Consulting SAS, F-69230 Saint Genis Laval, France.
FAU - Gallagher, Alison M
AU  - Gallagher AM
AD  - Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, 
      Coleraine, UK.
FAU - de Graaf, Kees
AU  - de Graaf K
AD  - Division of Human Nutrition and Health, Wageningen, The Netherlands.
FAU - Goscinny, Severine
AU  - Goscinny S
AD  - Service Organic Contaminants and Additives (SCIENSANO), Brussels, Belgium.
FAU - Hardman, Charlotte A
AU  - Hardman CA
AD  - Department of Psychological Sciences, University of Liverpool, Liverpool, UK.
FAU - Laviada-Molina, Hugo
AU  - Laviada-Molina H
AD  - Escuela de Ciencias de la Salud, Universidad Marista de Merida, Merida, Mexico.
FAU - Lopez-Garcia, Rebeca
AU  - Lopez-Garcia R
AD  - Logre International Food Science Consulting, Mexico City, Mexico.
FAU - Magnuson, Berna
AU  - Magnuson B
AD  - Health Science Consultants, Inc., Mississauga, Ontario, Canada.
FAU - Mellor, Duane
AU  - Mellor D
AD  - Aston Medical School, Aston University, Birmingham, UK.
FAU - Rogers, Peter J
AU  - Rogers PJ
AD  - Nutrition and Behaviour Unit, School of Psychological Science, University of 
      Bristol, Bristol, UK.
FAU - Rowland, Ian
AU  - Rowland I
AD  - Department of Food and Nutritional Sciences, University of Reading, Reading, UK.
FAU - Russell, Wendy
AU  - Russell W
AD  - University of Aberdeen Rowett Institute, Aberdeen, UK.
FAU - Sievenpiper, John L
AU  - Sievenpiper JL
AD  - Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
AD  - Division of Endocrinology and Metabolism, Department of Medicine, St. Michael's 
      Hospital, Toronto, Canada.
AD  - Li Ka Shing Knowledge Institute, St. Michael's, Toronto, Canada.
FAU - la Vecchia, Carlo
AU  - la Vecchia C
AD  - Department of Clinical Sciences and Community Health, University of Milan, Milan, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200113
PL  - England
TA  - Nutr Res Rev
JT  - Nutrition research reviews
JID - 9113797
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Appetite
MH  - Consensus
MH  - Diet
MH  - *Energy Intake
MH  - Humans
MH  - *Sweetening Agents/adverse effects
PMC - PMC7282854
OTO - NOTNLM
OT  - Consensus Reports
OT  - Food safety
OT  - Glucose control
OT  - Low-calorie sweeteners
OT  - Nutrition policy
OT  - Weight management
EDAT- 2020/01/14 06:00
MHDA- 2021/10/29 06:00
PMCR- 2020/06/09
CRDT- 2020/01/14 06:00
PHST- 2020/01/14 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2020/01/14 06:00 [entrez]
PHST- 2020/06/09 00:00 [pmc-release]
AID - S0954422419000283 [pii]
AID - 10.1017/S0954422419000283 [doi]
PST - ppublish
SO  - Nutr Res Rev. 2020 Jun;33(1):145-154. doi: 10.1017/S0954422419000283. Epub 2020 
      Jan 13.