PMID- 3192924
OWN - NLM
STAT- MEDLINE
DCOM- 19890110
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 7
IP  - 2
DP  - 1988 Oct
TI  - Serum bilirubin fractions in analbuminemic rats after bile duct ligation. Albumin 
      requirement in the formation of covalently protein-bound bilirubin.
PG  - 224-8
AB  - To clarify the role of albumin in the production of covalently protein-bound 
      bilirubin (delta bilirubin, B delta) in the blood and the pathophysiological 
      relevance of B delta, changes in the serum bilirubin level and histological 
      findings in the liver, kidneys and myocardium were studied in Sprague-Dawley (SD) 
      rats and Nagase analbuminemic rats (NAR) after bile duct ligation (BDL). In SD 
      rats, the serum bilirubin level increased until 3 days after BDL, and was 
      followed by the appearance of B delta. The increase in serum bilirubin was 
      smaller in NAR, and no serum B delta was noted. Albumin administration to NAR 1 
      day after BDL increased serum bilirubin with the appearance of B delta. Serum 
      bilirubin decreased in both SD rats and NAR 7 days after BDL. Marked deposition 
      of bile pigments was noted in NAR in the renal tubular epithelium. The renal 
      bilirubin content was decreased after albumin administration. From these results 
      it is concluded that albumin is necessary for the production of B delta, and that 
      renal deposition of bile pigments progresses in the absence of albumin.
FAU - Adachi, Y
AU  - Adachi Y
AD  - Second Department of Internal Medicine, Kinki University School of Medicine, 
      Osaka, Japan.
FAU - Kambe, A
AU  - Kambe A
FAU - Yamashita, M
AU  - Yamashita M
FAU - Inufusa, H
AU  - Inufusa H
FAU - Nagase, S
AU  - Nagase S
FAU - Yamamoto, T
AU  - Yamamoto T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Serum Albumin)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Animals
MH  - *Bile Ducts
MH  - Bilirubin/*blood
MH  - Kidney/metabolism
MH  - Ligation
MH  - Male
MH  - Protein Binding
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serum Albumin/*deficiency
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - S0168-8278(88)80486-0 [pii]
AID - 10.1016/s0168-8278(88)80486-0 [doi]
PST - ppublish
SO  - J Hepatol. 1988 Oct;7(2):224-8. doi: 10.1016/s0168-8278(88)80486-0.