PMID- 31929734
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201005
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 17
IP  - 1
DP  - 2020
TI  - Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to 
      Type 2 Diabetes Mellitus and Obesity.
PG  - 13-20
LID - 10.7150/ijms.37110 [doi]
AB  - Diabetes mellitus (DM) is a chronic disease found worldwide. Notably, BKS.Cg- 
      Dock7(m) +/+ Lepr(db)/JNarl mice are useful animal models for studying type 2 
      diabetes mellitus (T2DM). In this study, we investigated casein kinase 2 alpha 1 
      (CSNK2A1) gene and protein expression in the liver tissues of mice at different 
      ages (4, 16, and 32 weeks) using real-time quantitative polymerase chain 
      reactions, western blotting, immunohistochemistry, and enzyme-linked 
      immunosorbent assay. Our data paved the way for exploring BKS.Cg- Dock7(m) +/+ 
      Lepr(db)/JNarl in the mouse model by demonstrating a significant increase in gene 
      and protein expression in T2DM (+Lepr(db)/+Lepr(db)) mouse liver when compared to 
      control (+Dock7(m)/+Dock7(m)) mouse liver. We also observed that CSNK2A1 protein 
      level in the serum of T2DM patient group was higher than that of the control 
      group, although the data was not statistically significant. Based on our 
      findings, we can now understand the role of CSNK2A1 gene upregulation when 
      encountering T2DM pathologies.
CI  - (c) The author(s).
FAU - Lan, Yu-Ching
AU  - Lan YC
AD  - Department of Health Risk Management, China Medical University, 40402 Taichung, 
      Taiwan.
FAU - Wang, Yeh-Han
AU  - Wang YH
AD  - Department of Anatomical Pathology, Taipei Institute of Pathology, School of 
      Medicine, National Yang-Ming University , 11221 Taipei, Taiwan.
FAU - Chen, Hsin-Han
AU  - Chen HH
AD  - Division of Plastic and Reconstructive Surgery, China Medical University 
      Hospital, 40402 Taichung, Taiwan.
FAU - Lo, Sui-Foon
AU  - Lo SF
AD  - School of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan.
FAU - Chen, Shih-Yin
AU  - Chen SY
AD  - School of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan.
AD  - Genetics Center, Medical Research, China Medical University Hospital, 40447 
      Taichung, Taiwan.
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
AD  - School of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan.
AD  - Genetics Center, Medical Research, China Medical University Hospital, 40447 
      Taichung, Taiwan.
AD  - Department of Medical Genetics, China Medical University Hospital, 40447 
      Taichung, Taiwan, R.O.C.
LA  - eng
PT  - Journal Article
DEP - 20200101
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Blood Glucose)
RN  - 0 (Receptors, Leptin)
RN  - 0 (leptin receptor, mouse)
RN  - EC 2.7.11.1 (CSNK2A1 protein, human)
RN  - EC 2.7.11.1 (Casein Kinase II)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Blood Glucose
MH  - Casein Kinase II/genetics
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation/genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Liver/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Middle Aged
MH  - Obesity/*genetics/pathology
MH  - Receptors, Leptin/*genetics
PMC - PMC6945564
OTO - NOTNLM
OT  - +Leprdb / +Leprdb mice
OT  - Casein Kinase 2 Alpha 1 (CSNK2A1).
OT  - T2DM
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2020/01/14 06:00
MHDA- 2020/10/06 06:00
PMCR- 2020/01/01
CRDT- 2020/01/14 06:00
PHST- 2019/05/29 00:00 [received]
PHST- 2019/09/18 00:00 [accepted]
PHST- 2020/01/14 06:00 [entrez]
PHST- 2020/01/14 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijmsv17p0013 [pii]
AID - 10.7150/ijms.37110 [doi]
PST - epublish
SO  - Int J Med Sci. 2020 Jan 1;17(1):13-20. doi: 10.7150/ijms.37110. eCollection 2020.