PMID- 31930032
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 7
IP  - 22
DP  - 2019 Nov
TI  - Effect of simultaneous pancreas-kidney transplantation on blood glucose level for 
      patients with end-stage renal disease with type 1 and type 2 diabetes.
PG  - 631
LID - 10.21037/atm.2019.10.106 [doi]
LID - 631
AB  - BACKGROUND: Simultaneous pancreas-kidney (SPK) transplants for patients with type 
      1 diabetes mellitus (T1DM) remains disproportionately higher than that for type 2 
      diabetes mellitus (T2DM) patients. However, understanding the surgical outcomes 
      for these patients is not well described. Therefore, the results of DM patients 
      with end-stage renal disease and their transplantations were reported. METHODS: 
      Between September 2016 and June 2019, 63 SPK transplants were performed in our 
      organ transplantation center. chi(2) and t-test compared the variables between the 
      groups and the record review verified the patient survival. Using Kaplan-Meier 
      survival estimates and Cox proportional hazards regression, we examined the 
      influence of SPK on patient and graft survivals. RESULTS: Sixty-three SPK 
      transplantation was performed, 18 (29%) were T1DM, and 45 (71%) T2DM. T2DM 
      recipients had older age, duration of diabetes, and pretransplant dialysis time. 
      No differences were found in human leukocyte antigen (HLA) mismatch, body mass 
      index (BMI), and other variables. Patient survivals for T1DM was 98.2% and 94.8% 
      at 1 and 2 years vs. 100% and 94.1% for T2DM recipients (P=0.87). There was no 
      increased risk between kidney disease, pancreas failure, or death when comparing 
      T2DM and T1DM. CONCLUSIONS: In our single-center cohort of SPK transplants, we 
      concluded that SPK recipients with T2DM diagnosis were not at increased risk for 
      death, kidney failure, or pancreas failure when compared with recipients with 
      T1DM.
CI  - 2019 Annals of Translational Medicine. All rights reserved.
FAU - Liu, Luhao
AU  - Liu L
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Xiong, Yunyi
AU  - Xiong Y
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Fang, Jiali
AU  - Fang J
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Li, Guanghui
AU  - Li G
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Xu, Lu
AU  - Xu L
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Lai, Xingqiang
AU  - Lai X
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Chen, Rongxin
AU  - Chen R
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Guo, Yuhe
AU  - Guo Y
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Pan, Guanghui
AU  - Pan G
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Ma, Junjie
AU  - Ma J
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
FAU - Chen, Zheng
AU  - Chen Z
AD  - Department of Organ Transplantation, The Second Affiliated Hospital of Guangzhou 
      Medical University, Guangzhou 511447, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC6944581
OTO - NOTNLM
OT  - Diabetes mellitus (DM)
OT  - kidney transplantation
OT  - simultaneous pancreas-kidney transplantation (SPK transplantation)
OT  - type 2 diabetes mellitus (T2DM)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/01/14 06:00
MHDA- 2020/01/14 06:01
PMCR- 2019/11/01
CRDT- 2020/01/14 06:00
PHST- 2020/01/14 06:00 [entrez]
PHST- 2020/01/14 06:00 [pubmed]
PHST- 2020/01/14 06:01 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - atm-07-22-631 [pii]
AID - 10.21037/atm.2019.10.106 [doi]
PST - ppublish
SO  - Ann Transl Med. 2019 Nov;7(22):631. doi: 10.21037/atm.2019.10.106.