PMID- 31931830
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20201117
IS  - 1742-2094 (Electronic)
IS  - 1742-2094 (Linking)
VI  - 17
IP  - 1
DP  - 2020 Jan 13
TI  - Blast traumatic brain injury and serum inflammatory cytokines: a repeated 
      measures case-control study among U.S. military service members.
PG  - 20
LID - 10.1186/s12974-019-1624-z [doi]
LID - 20
AB  - BACKGROUND: There is a paucity of human data on exposure to blast traumatic brain 
      injury (bTBI) and the corresponding systemic cytokine immune response at later 
      time points (i.e., months, years) post-injury. METHODS: We conducted a repeated 
      measures, case-control study, examining associations of serum levels of pro- and 
      anti-inflammatory cytokines, measured both pre- and post-deployment with having 
      mild and moderate/severe bTBI. Utilizing serum from the Department of Defense 
      Serum Repository cytokines were measured via an ELISA-based array for 15 
      cytokines. We compared pre- vs. post-levels among mild cases, moderate/severe 
      cases, and controls and carried out case-control comparisons, using paired t- 
      tests and generalized linear models. RESULTS: The average time between bTBI and 
      post-deployment/bTBI serum among cases was 315.8 days. From pre- to 
      post-deployment/bTBI, levels of interleukin 8 (IL-8) were decreased among both 
      mild cases (mu = - 83.43 pg/ml; s.e. = 21.66) and moderate/severe cases 
      (mu = - 107.67 pg/ml; s.e. = 28.74 pg/ml), while levels increased among controls 
      (mu = 32.86 pg/ml; s.e. = 30.29). The same pattern occurred for matrix 
      metallopeptidase 3 (MMP3), with levels decreasing for moderate/severe cases 
      (mu = - 3369.24 pg/ml; s.e. = 1701.68) and increasing for controls 
      (mu = 1859.60 pg/ml; s.e. = 1737.51) from pre- to post-deployment/bTBI. Evidence 
      was also suggestive of case-control differences, from pre- to 
      post-deployment/bTBI for interleukin 1 alpha (IL-1alpha), interleukin 4 (IL-4), and 
      interleukin 6 (IL-6) among moderate/severe cases. CONCLUSION: The findings of 
      this longitudinal study indicate that in the chronic phase of bTBI, levels of 
      IL-8 and MMP3 may be substantially lower than pre-injury. These results need 
      confirmation in other studies, potentially those that account for treatment 
      differences, which was not possible in our study.
FAU - Rusiecki, Jennifer
AU  - Rusiecki J
AD  - Department of Preventive Medicine and Biostatistics, F. Edward Hebert School of 
      Medicine, Uniformed Services University, Bethesda, MD, USA. 
      jennifer.rusiecki@usuhs.edu.
FAU - Levin, Lynn I
AU  - Levin LI
AD  - Statistics and Epidemiology Branch, Walter Reed Army Institute of Research, 
      Silver Spring, MD, USA.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Preventive Medicine and Biostatistics, F. Edward Hebert School of 
      Medicine, Uniformed Services University, Bethesda, MD, USA.
FAU - Byrne, Celia
AU  - Byrne C
AD  - Department of Preventive Medicine and Biostatistics, F. Edward Hebert School of 
      Medicine, Uniformed Services University, Bethesda, MD, USA.
FAU - Krishnamurthy, Jayasree
AU  - Krishnamurthy J
AD  - Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services 
      University, Bethesda, MD, USA.
FAU - Chen, Ligong
AU  - Chen L
AD  - Department of Preventive Medicine and Biostatistics, F. Edward Hebert School of 
      Medicine, Uniformed Services University, Bethesda, MD, USA.
FAU - Galdzicki, Zygmunt
AU  - Galdzicki Z
AD  - Department of Anatomy, Physiology, and Genetics, F. Edward Hebert School of 
      Medicine, Uniformed Services University, Bethesda, MD, USA.
FAU - French, Louis M
AU  - French LM
AD  - National Intrepid Center of Excellence, Walter Reed National Military Medical 
      Center, Bethesda, MD, USA.
LA  - eng
GR  - PT073882/Congressionally Directed Medical Research Programs/
PT  - Journal Article
DEP - 20200113
PL  - England
TA  - J Neuroinflammation
JT  - Journal of neuroinflammation
JID - 101222974
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Blast Injuries/*blood/*complications/immunology
MH  - Brain Injuries, Traumatic/*blood/*etiology/immunology
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Inflammation/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Military Personnel
MH  - Young Adult
PMC - PMC6958571
OTO - NOTNLM
OT  - Cytokines
OT  - Inflammation
OT  - Microarray
OT  - Military
OT  - Operation Iraqi freedom
OT  - Operation enduring freedom
OT  - Protein
OT  - TBI
OT  - Traumatic brain injury
COIS- The authors declare that they have no competing interests.
EDAT- 2020/01/15 06:00
MHDA- 2020/11/18 06:00
PMCR- 2020/01/13
CRDT- 2020/01/15 06:00
PHST- 2019/05/07 00:00 [received]
PHST- 2019/10/28 00:00 [accepted]
PHST- 2020/01/15 06:00 [entrez]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/01/13 00:00 [pmc-release]
AID - 10.1186/s12974-019-1624-z [pii]
AID - 1624 [pii]
AID - 10.1186/s12974-019-1624-z [doi]
PST - epublish
SO  - J Neuroinflammation. 2020 Jan 13;17(1):20. doi: 10.1186/s12974-019-1624-z.