PMID- 31932174
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 218
DP  - 2020 Apr
TI  - Neurotrophic factor changes are essential for predict electroconvulsive therapy 
      outcome in schizophrenia.
PG  - 295-297
LID - S0920-9964(19)30470-0 [pii]
LID - 10.1016/j.schres.2019.10.035 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in the treatment 
      of schizophrenia with electroconvulsive therapy (ECT) or antipsychotic (AP) 
      drugs. However, it is unclear whether BDNF is a mediator; we therefore assumed 
      that baseline BDNF level can mediate the efficacy of ECT-AP treatment. A total of 
      160 patients with schizophrenia were examined; 80 received AP monotherapy and the 
      other 80 were treated with a combination of ECT and AP. BDNF concentration was 
      measured by enzyme-linked immunosorbent assay using the Emax Immunoassay System 
      kit (Promega, Madison, WI, USA) according to the manufacturer's 
      instructions.Log-linear analyses were used to examine the relationship between 
      demographic characteristics, BDNF level, and clinical features and response 
      status. The baseline BDNF levels and BDNF level increment were the best 
      predictors of clinical outcome (OR1 = 3.358, P = 0.000; OR2 = 3.243, 
      P = 0.000).The higher baseline BDNF levels and greater BDNF level increment were 
      found to be associated with good outcome.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Li, Jin
AU  - Li J
AD  - Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji 
      Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: 
      273832265@qq.com.
FAU - Zhang, Xiaobin
AU  - Zhang X
AD  - Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji 
      Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: 
      zhangxiaobim@163.com.
FAU - Tang, Xiaowei
AU  - Tang X
AD  - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of 
      Yangzhou University, Yangzhou, 225003, China. Electronic address: 
      shrimp200@aliyun.com.
FAU - Xiao, Wenhuan
AU  - Xiao W
AD  - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of 
      Yangzhou University, Yangzhou, 225003, China. Electronic address: 
      931610937@qq.com.
FAU - Ye, Fei
AU  - Ye F
AD  - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of 
      Yangzhou University, Yangzhou, 225003, China. Electronic address: bksh-y@163.com.
FAU - Sha, Weiwei
AU  - Sha W
AD  - Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of 
      Yangzhou University, Yangzhou, 225003, China. Electronic address: 
      sww63723@sohu.com.
FAU - Jia, Qiufang
AU  - Jia Q
AD  - Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji 
      Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: 
      jiaqfjc@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200110
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Antipsychotic Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor
MH  - *Electroconvulsive Therapy
MH  - Humans
MH  - *Schizophrenia/therapy
OTO - NOTNLM
OT  - Antipsychotic drugs
OT  - Brain-derived neurotrophic factor
OT  - Electroconvulsive therapy
OT  - Enzyme-linked immunosorbent assay
OT  - Predictive model
OT  - Schizophrenia
COIS- Declaration of competing interest The Authors declare that they have no conflicts 
      of interest in relation to the subject of this study.
EDAT- 2020/01/15 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/01/15 06:00
PHST- 2018/12/23 00:00 [received]
PHST- 2019/09/09 00:00 [revised]
PHST- 2019/10/12 00:00 [accepted]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/01/15 06:00 [entrez]
AID - S0920-9964(19)30470-0 [pii]
AID - 10.1016/j.schres.2019.10.035 [doi]
PST - ppublish
SO  - Schizophr Res. 2020 Apr;218:295-297. doi: 10.1016/j.schres.2019.10.035. Epub 2020 
      Jan 10.