PMID- 31933123
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1880-4233 (Electronic)
IS  - 1340-6868 (Linking)
VI  - 27
IP  - 4
DP  - 2020 Jul
TI  - The number of FoxP3-positive tumor-infiltrating lymphocytes in patients with 
      synchronous bilateral breast cancer.
PG  - 586-593
LID - 10.1007/s12282-020-01049-4 [doi]
AB  - PURPOSE: In breast cancer, FoxP3-positive tumor-infiltrating lymphocytes 
      (FoxP3+ TILs) vary depending on lymph node status, histological grade, and 
      subtype. All these studies have compared the numbers of FoxP3+ TILs among 
      different hosts, but recruitment of FoxP3+ TILs might depend on each individual's 
      immune environment and each tumor's biological characteristics. In the present 
      study, FoxP3+ TIL numbers were investigated in patients with synchronous 
      bilateral breast cancer (SBBC) to determine the factors that affect FoxP3+ TIL 
      recruitment in the same anti-tumor immune environment. METHODS: Patients 
      diagnosed with SBBC who underwent curative surgery at two institutions were 
      enrolled in this study. Patients who underwent primary systemic therapy or who 
      were diagnosed with ductal carcinoma in situ or who had distant metastases at 
      diagnosis were excluded. The average numbers of Foxp3+ TILs were determined from 
      the scores of five high-power microscopic fields (HPF). The associations between 
      Foxp3+ TIL numbers and the clinicopathological features of bilateral breasts in a 
      single individual were examined. RESULTS: Nuclear grade (NG) (p = 0.007) and 
      subtype (p = 0.03), but not size (p = 0.18) and axillary lymph node (p = 0.23) 
      were significantly associated with increase of FoxP3 + TIL numbers by univariate 
      analysis. Further, only NG was a statistically significant clinicopathological 
      factor for change in the number of FoxP3+ TILs by multivariate analysis 
      (p = 0.046) CONCLUSIONS: There was no relationship between FoxP3+ TIL numbers and 
      cancer progression as reflected in tumor size and axillary lymph node in patients 
      with SBBC. Aggressive biological factors, especially high NG, were significantly 
      related to enhanced recruitment of FoxP3+ TILs.
FAU - Goto, Risa
AU  - Goto R
AUID- ORCID: 0000-0002-5956-3209
AD  - Department of Breast Surgical Oncology, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center Komagome Hospital, 3-18-22 Honkomagome Bunkyoku, Tokyo, Japan. 
      rg02045@cick.jp.
AD  - Department of Pathology, Showa University, Tokyo, Japan. rg02045@cick.jp.
FAU - Hirota, Yuko
AU  - Hirota Y
AD  - Department of Pathology, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Aruga, Tomoyuki
AU  - Aruga T
AD  - Department of Breast Surgical Oncology, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center Komagome Hospital, 3-18-22 Honkomagome Bunkyoku, Tokyo, Japan.
FAU - Horiguchi, Shinichiro
AU  - Horiguchi S
AD  - Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center 
      Komagome Hospital, Tokyo, Japan.
FAU - Miura, Sakiko
AU  - Miura S
AD  - Department of Pathology, Showa University, Tokyo, Japan.
FAU - Nakamura, Seigo
AU  - Nakamura S
AD  - Department of Surgery, Division of Breast Surgical Oncology, Showa University, 
      Tokyo, Japan.
FAU - Takimoto, Masafumi
AU  - Takimoto M
AD  - Department of Pathology, Showa University, Tokyo, Japan.
LA  - eng
GR  - H290303015/Clinical Research Found of Tokyo Metropolitan Government/
PT  - Journal Article
DEP - 20200113
PL  - Japan
TA  - Breast Cancer
JT  - Breast cancer (Tokyo, Japan)
JID - 100888201
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Axilla
MH  - Breast/immunology/pathology/surgery
MH  - Breast Neoplasms/*immunology/pathology/surgery
MH  - Disease Progression
MH  - Female
MH  - Forkhead Transcription Factors/metabolism
MH  - Humans
MH  - Lymph Nodes/pathology
MH  - Lymphocyte Count
MH  - Lymphocytes, Tumor-Infiltrating/*immunology/metabolism
MH  - Mastectomy
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasms, Multiple Primary/*immunology/pathology/surgery
MH  - Retrospective Studies
MH  - Tumor Microenvironment/*immunology
OTO - NOTNLM
OT  - Anti-tumor immunity environment
OT  - FoxP3
OT  - Regulatory T cell
OT  - Synchronous bilateral breast cancer
OT  - Tumor-infiltrating lymphocytes
EDAT- 2020/01/15 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/01/15 06:00
PHST- 2019/09/21 00:00 [received]
PHST- 2020/01/05 00:00 [accepted]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/01/15 06:00 [entrez]
AID - 10.1007/s12282-020-01049-4 [pii]
AID - 10.1007/s12282-020-01049-4 [doi]
PST - ppublish
SO  - Breast Cancer. 2020 Jul;27(4):586-593. doi: 10.1007/s12282-020-01049-4. Epub 2020 
      Jan 13.