PMID- 31933125
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20210104
IS  - 1559-0291 (Electronic)
IS  - 0273-2289 (Linking)
VI  - 191
IP  - 1
DP  - 2020 May
TI  - Surface Functionalization of Poly(N-Vinylpyrrolidone) onto Poly(Dimethylsiloxane) 
      for Anti-Biofilm Application.
PG  - 29-44
LID - 10.1007/s12010-020-03238-5 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) has been widely used in the field of microfluidics, 
      optical systems, and sensors. However, the hydrophobic nature of PDMS leads to 
      low surface wettability and biofouling problems due to the nonspecific 
      proteins-hydrophobic surface interactions and cell/bacterial adhesion. In this 
      work, the PDMS surface was first introduced with amino groups (PDMS-NH2) via 
      KOH-catalyzed reaction with 3-aminopropyltriethoxysilane (APTES). The PDMS-NH2 
      was then grafted with poly(N-vinylpyrrolidone) (PVP) based on the self-adhesion 
      reaction between the amino surface and catechol-functionalized PVP (CA-PLL-PVP). 
      CA-PLL-PVP as a comb-polymer was synthesized by conjugating PVP-COOH along with 
      caffeic acid to the epsilon-polylysine backbone. A significantly enhanced water 
      wettability was observed with contact angles dropped from 116 degrees  to 14 degrees  after 
      coating with CA-PLL-PVP. The coated surface demonstrated excellent antifouling 
      performance that no appreciable Staphylococcus epidermidis biofilm formation 
      could be observed. This novel facile antifouling coating on PDMS surface may find 
      greater biomedical applications to eliminate the potential adherence problems 
      caused by natural biofouling.
FAU - Le, Trong-Nghia
AU  - Le TN
AD  - Department of Chemical Engineering, National Taiwan University of Science and 
      Technology, 43 Keelung Rd. Sec. 4, Taipei, Taiwan, 106.
FAU - Lee, Cheng-Kang
AU  - Lee CK
AD  - Department of Chemical Engineering, National Taiwan University of Science and 
      Technology, 43 Keelung Rd. Sec. 4, Taipei, Taiwan, 106. cklee@mail.ntust.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20200114
PL  - United States
TA  - Appl Biochem Biotechnol
JT  - Applied biochemistry and biotechnology
JID - 8208561
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 25249-54-1 (polyvinylpolypyrrolidone)
RN  - 63148-62-9 (baysilon)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - Anti-Infective Agents/*chemistry
MH  - Biofilms/*growth & development
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Povidone/*analogs & derivatives/chemistry
MH  - Staphylococcus epidermidis/*physiology
MH  - Surface Properties
OTO - NOTNLM
OT  - Anti-biofilm
OT  - Catechol-assisted coating
OT  - PDMS
OT  - PVP copolymer
EDAT- 2020/01/15 06:00
MHDA- 2021/01/05 06:00
CRDT- 2020/01/15 06:00
PHST- 2019/09/24 00:00 [received]
PHST- 2020/01/08 00:00 [accepted]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2020/01/15 06:00 [entrez]
AID - 10.1007/s12010-020-03238-5 [pii]
AID - 10.1007/s12010-020-03238-5 [doi]
PST - ppublish
SO  - Appl Biochem Biotechnol. 2020 May;191(1):29-44. doi: 10.1007/s12010-020-03238-5. 
      Epub 2020 Jan 14.