PMID- 31934041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200117
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 12
IP  - 6
DP  - 2019
TI  - Clinical significance of USP7 and EZH2 in predicting prognosis of laryngeal 
      squamous cell carcinoma and their possible functional mechanism.
PG  - 2184-2194
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent 
      cancer types in the world. The ubiquitin specific protease 7 (USP7), a kind of 
      deubiquitylating enzyme, has been reported to play multifaceted roles in 
      different tumor types. EZH2 has been found to be highly expressed in various 
      malignantcells and high expression of EZH2 is closely related to tumor growth 
      infiltration, lymph node involvement, clinical stage, and poor prognosis. The aim 
      of this study was to investigate the expression and function of USP7 and EZH2 in 
      LSCC. CASE PRESENTATION: Immunohistochemical staining and histochemical staining 
      were performed to explore the expression of USP7 and EZH2 in both LSCC tissues 
      and adjacent normal laryngeal tissues. Chi-square test, univariate analysis, and 
      multivariate analysis were conducted to statistically evaluate the clinical 
      significance of USP7 and EZH2. CONCLUSIONS: USP7and EZH2 affects LSCC evolution; 
      USP7 and EZH2 were upregulated in LSCC tissues, which can serve as independent 
      prognostic predictors, and potential therapeutic targets for LSCC.
CI  - IJCEP Copyright (c) 2019.
FAU - Zhang, Ming-Jie
AU  - Zhang MJ
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Bengbu 
      Medical University Bengbu, Anhui, China.
FAU - Chen, De-Shang
AU  - Chen DS
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Bengbu 
      Medical University Bengbu, Anhui, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Bengbu 
      Medical University Bengbu, Anhui, China.
FAU - Liu, Wei-Wei
AU  - Liu WW
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Bengbu 
      Medical University Bengbu, Anhui, China.
FAU - Han, Guo-Ying
AU  - Han GY
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Bengbu 
      Medical University Bengbu, Anhui, China.
FAU - Han, Yue-Feng
AU  - Han YF
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Bengbu 
      Medical University Bengbu, Anhui, China.
LA  - eng
PT  - Journal Article
DEP - 20190601
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6949638
OTO - NOTNLM
OT  - EZH2
OT  - Laryngeal squamous cell carcinoma
OT  - USP7
OT  - lymphatic invasion
COIS- None.
EDAT- 2020/01/15 06:00
MHDA- 2020/01/15 06:01
PMCR- 2019/06/01
CRDT- 2020/01/15 06:00
PHST- 2019/02/04 00:00 [received]
PHST- 2019/02/26 00:00 [accepted]
PHST- 2020/01/15 06:00 [entrez]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/01/15 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2019 Jun 1;12(6):2184-2194. eCollection 2019.