PMID- 31934052
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200117
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 12
IP  - 6
DP  - 2019
TI  - Renal amyloidosis complicated by light chain deposition nephropathy: a case 
      report.
PG  - 2279-2283
AB  - Light chain amyloidosis (AL) and light chain deposition disease (LCDD) are 
      systemic diseases caused by an abnormal production of monoclonal immunoglobulin 
      light chains and their deposition in systemic tissue. We herein present a rare 
      case of renal amyloidosis complicated with light chain deposition nephropathy. 
      The patient presented with nephrotic syndrome and an increased serum creatinine. 
      Laboratory studies showed the serum k light chain was decreased and the urine 
      free lambda light chain was positive. On a lighted microscopy examination of the renal 
      cortical tissue, lambda and kappa light chain protein deposits were in the glomerular and 
      renal tubular basement membranes and Congo red staining was positive. It was 
      determined using electron microscopy that amyloid fibrils and continuous 
      electron-dense granules were deposited in the glomerular basement membrane. Due 
      to differences in the protein polymerization mechanisms, it is almost impossible 
      for AL and LCDD to coexist. This rare case can help provide ideas for clinical 
      diagnosis and for exploring new therapeutic targets.
CI  - IJCEP Copyright (c) 2019.
FAU - Yu, Xiaoyang
AU  - Yu X
AD  - Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Xi'an, Shaanxi, China.
FAU - Lan, Ping
AU  - Lan P
AD  - Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Xi'an, Shaanxi, China.
FAU - Feng, Jie
AU  - Feng J
AD  - Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Xi'an, Shaanxi, China.
FAU - Feng, Xueliang
AU  - Feng X
AD  - Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Xi'an, Shaanxi, China.
FAU - Xie, Liyi
AU  - Xie L
AD  - Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong 
      University Xi'an, Shaanxi, China.
LA  - eng
PT  - Case Reports
DEP - 20190601
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6949640
OTO - NOTNLM
OT  - Renal amyloidosis
OT  - light chain deposition
OT  - monoclonal immunoglobulin
COIS- None.
EDAT- 2020/01/15 06:00
MHDA- 2020/01/15 06:01
PMCR- 2019/06/01
CRDT- 2020/01/15 06:00
PHST- 2019/03/10 00:00 [received]
PHST- 2019/03/27 00:00 [accepted]
PHST- 2020/01/15 06:00 [entrez]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/01/15 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2019 Jun 1;12(6):2279-2283. eCollection 2019.