PMID- 31934089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200325
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 12
IP  - 7
DP  - 2019
TI  - Spindle cell lipoma: clinicopathologic characterization of 40 cases.
PG  - 2613-2621
AB  - OBJECTIVE: In view of the existence of multifarious pathologic subtypes of 
      spindle cell lipoma (SCL), which is easily misdiagnosed as other benign and 
      malignant soft tissue tumors, we performed this study and aimed to better define 
      the category of SCL. METHODS: We collected and analyzed 40 cases of SCL with 
      complete clinical and pathologic information from January 2010 to December 2018. 
      Clinical and histopathologic analyses of SCL were performed, as well as 
      immunohistochemical staining and fluorescence in situ hybridization (FISH) using 
      probes for RB1 and MDM2, and the related literature was reviewed. RESULTS: In 40 
      cases, the male to female ratio was 3.4:1, and the mean age was 54 years old. SCL 
      of our study included six pathologic subtypes: classic (25/40), fibrous (4/40), 
      myxoid (4/40), low-fat (3/40), pseudoangiomatous (2/40), and fat-rich (2/40) 
      changes. Microscopically, SCL showed distinctive morphology, with uniform spindle 
      cells and a variably adipocytic component. The spindle cells were bland in 
      morphology, without prominent atypia or pleomorphism, set in a myxoid or fibrous 
      matrix. Immunohistochemically, CD34 and vimentin were positive in spindle cells, 
      and spindle cells of 6 cases also expressed S-100 protein. FISH analysis of 10 
      cases revealed that heterozygous deletion of RB1 was in six samples with 
      chromosome 13 aberrations and MDM2 gene amplification was not detected in any 
      cases. Surgical resection is considered as the primary treatment for SCL, as 
      there was no any recurrence or metastasis in our cases after 2-105 months of 
      follow-up. CONCLUSIONS: SCL is a rare benign lipoma, and the proportion of 
      spindle cells and adipocytic component varies, which may form various pathologic 
      changes. The diagnosis needs to be combined with clinicopathologic features, 
      immunophenotypes, and genetics. It has to be differentiated from mammary-type 
      myofibroblastoma, cellular angiolipoma, solitary fibrous tumor, and myxoid 
      liposarcoma.
CI  - IJCEP Copyright (c) 2019.
FAU - Chen, Shuai
AU  - Chen S
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University Jining, 
      Shandong Province, P. R. China.
FAU - Huang, Haining
AU  - Huang H
AD  - Department of Pharmacy, Affiliated Hospital of Jining Medical University Jining, 
      Shandong Province, P. R. China.
FAU - He, Shujin
AU  - He S
AD  - Clinical College, Jining Medical University Jining, Shandong Province, P. R. 
      China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University Jining, 
      Shandong Province, P. R. China.
FAU - Zhao, Ran
AU  - Zhao R
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University Jining, 
      Shandong Province, P. R. China.
FAU - Li, Lei
AU  - Li L
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University Jining, 
      Shandong Province, P. R. China.
FAU - Cui, Zhihong
AU  - Cui Z
AD  - Department of Pathology, The Second People's Hospital of Jining Jining, Shandong 
      Province, P. R. China.
FAU - Zhang, Renya
AU  - Zhang R
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University Jining, 
      Shandong Province, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20190701
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6949558
OTO - NOTNLM
OT  - MDM2
OT  - RB1
OT  - S-100
OT  - Spindle cell lipoma (SCL)
OT  - differential diagnosis
COIS- None.
EDAT- 2020/01/15 06:00
MHDA- 2020/01/15 06:01
PMCR- 2019/07/01
CRDT- 2020/01/15 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/04/23 00:00 [accepted]
PHST- 2020/01/15 06:00 [entrez]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/01/15 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2019 Jul 1;12(7):2613-2621. eCollection 2019.