PMID- 31934159
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200325
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 12
IP  - 8
DP  - 2019
TI  - Embryonal tumor with multilayered rosettes, C19MC-altered (ETMR): a newly defined 
      pediatric brain tumor.
PG  - 3156-3163
AB  - Embryonal tumor with multilayered rosettes (ETMR), C19MC-altered, is a newly 
      defined and rare pediatric malignant tumor of the central nervous system (CNS) in 
      the 2016 WHO Classification of Tumors of the Central Nervous System. Here we 
      present two cases of ETMR with amplification of the C19MC locus at chromosome 
      19q13.42. Case 1 is a fifteen-year-old boy, who underwent gamma knife surgery two 
      times three years ago, after presenting with seizures. Magnetic resonance imaging 
      (MRI) identified a large mass in the left frontotemporal lobe. Case 2 is a 
      three-year-old boy who underwent surgery for a right frontal lobe tumor followed 
      by chemotherapy. Eight months later, MRI identified a recurrent tumor in the 
      bilateral frontal lobe. Histologically, cases 1 and 2 exhibited a typical 
      papillary/trabecular and a multilayered rosette pattern resembling 
      medulloepithelioma (ME) and ependymoblastoma (EBL), respectively. 
      Immunohistochemically, CD99, synaptophysin, vimentin, and LIN28A were positive in 
      both cases. Most importantly, both cases displayed amplification in the C19MC 
      locus at 19q13.42 in a fluorescence in situ hybridization (FISH) analysis.
CI  - IJCEP Copyright (c) 2019.
FAU - Pei, Yu-Chun
AU  - Pei YC
AD  - Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University 
      Chongqing 400037, China.
FAU - Huang, Guo-Hao
AU  - Huang GH
AD  - Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University 
      Chongqing 400037, China.
FAU - Yao, Xiao-Hong
AU  - Yao XH
AD  - Department of Pathology, Southwest Hospital, Third Military Medical University 
      Chongqing 400038, China.
FAU - Bian, Xiu-Wu
AU  - Bian XW
AD  - Department of Pathology, Southwest Hospital, Third Military Medical University 
      Chongqing 400038, China.
FAU - Li, Fei
AU  - Li F
AD  - Department of Neurosurgery, Southwest Hospital, Third Military Medical University 
      Chongqing 400038, China.
FAU - Xiang, Yan
AU  - Xiang Y
AD  - Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University 
      Chongqing 400037, China.
FAU - Yang, Lin
AU  - Yang L
AD  - Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University 
      Chongqing 400037, China.
FAU - Lv, Sheng-Qing
AU  - Lv SQ
AD  - Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University 
      Chongqing 400037, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University 
      Chongqing 400037, China.
LA  - eng
PT  - Journal Article
DEP - 20190801
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6949702
OTO - NOTNLM
OT  - C19MC locus
OT  - Embryonal tumor with multilayered rosettes (ETMR)
OT  - LIN28A
OT  - amplification
OT  - chromosome 19q13.42
COIS- None.
EDAT- 2020/01/15 06:00
MHDA- 2020/01/15 06:01
PMCR- 2019/08/01
CRDT- 2020/01/15 06:00
PHST- 2019/03/20 00:00 [received]
PHST- 2019/04/18 00:00 [accepted]
PHST- 2020/01/15 06:00 [entrez]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/01/15 06:01 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2019 Aug 1;12(8):3156-3163. eCollection 2019.