PMID- 31934198
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220718
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 12
IP  - 9
DP  - 2019
TI  - Association between sex hormone binding globulin gene polymorphism and type 2 
      diabetes mellitus.
PG  - 3514-3520
AB  - This study aims to investigate the relationship between single nucleotide 
      polymorphisms (SNPs) of sex hormone binding globulin (SHBG) and type 2 diabetes 
      mellitus (T2DM) in an Uighur population. One hundred and fourteen T2DM male 
      patients (with a history of diabetes or diagnosed as diabetic by the oral glucose 
      tolerance test) and 173 healthy males from the Uighur ethnic group were included 
      in the study to test the following SNPs of SHBG: rs727428, rs1799941, rs6259, 
      rs6257, rs858521, rs858518, rs3760213, and rs11078701. The body mass index (BMI), 
      blood pressure, and waist circumference, and lipid, glucose, HbA1c, insulin, 
      HOMA-IR, testosterone, and SHBG levels of enrolled individuals were measured. We 
      used the t-test or rank sum test and Chi-square test to analyze the difference 
      and compare numeration data, respectively, between the case and control groups. 
      Comparisons among multiple groups were carried out using analysis of variance, 
      and the correlation between variables was determined by nonparametric Spearman 
      rank correlation analysis; multivariate logistic regression analysis was used to 
      assess the risk of abnormal glucose in the two groups. There was a significant 
      difference (P < 0.05) in BMI, blood pressure, and waist circumference, and lipid, 
      glucose, HbA1c, insulin, and HOMA-IR levels between the case and control groups. 
      The risk factors for diabetes included testosterone (P = 0.042) and SHBG (P = 
      0.001). The distribution of rs858521 (P = 0.001), rs1799941 (2.3%, P = 0.032), 
      rs6259 (2.5%, P = 0.040), and rs727428 (3.4%, P = 0.016) was significantly 
      different between the case and control groups (P < 0.05). In the control group, 
      there was linkage disequilibrium (LD) between rs727428 and rs6259, while in the 
      case group LD was found among rs858518, rs3760213, rs1799941, and rs6257. The 
      frequency of rs858518-rs3760213-rs1799941-rs6257 haplotype TCGC was significantly 
      different between the two groups (P = 0.033). Both testosterone and SHBGwere 
      found to be risk factors of diabetes in the Uighur population, and SNPs of SHBG 
      may contribute to T2DM.
CI  - IJCEP Copyright (c) 2019.
FAU - Quan, Li
AU  - Quan L
AD  - Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical 
      University Urumqi, China.
FAU - Wang, Liang
AU  - Wang L
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang 
      Medical University Urumqi, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical 
      University Urumqi, China.
FAU - Yuwen, Binya
AU  - Yuwen B
AD  - Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical 
      University Urumqi, China.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical 
      University Urumqi, China.
LA  - eng
PT  - Journal Article
DEP - 20190901
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6949838
OTO - NOTNLM
OT  - Diabetes
OT  - Uighur ethnic group
OT  - sex hormone binding globulin (SHBG)
OT  - single Nucleotide Polymorphism (SNPs)
COIS- None.
EDAT- 2020/01/15 06:00
MHDA- 2020/01/15 06:01
PMCR- 2019/09/01
CRDT- 2020/01/15 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/08/26 00:00 [accepted]
PHST- 2020/01/15 06:00 [entrez]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/01/15 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2019 Sep 1;12(9):3514-3520. eCollection 2019.