PMID- 3193449
OWN - NLM
STAT- MEDLINE
DCOM- 19890110
LR  - 20131121
IS  - 0047-2565 (Print)
IS  - 0047-2565 (Linking)
VI  - 17
IP  - 4
DP  - 1988
TI  - Comparative teratogenicity of triamcinolone acetonide and dexamethasone in the 
      rhesus monkey (Macaca mulatta).
PG  - 195-203
AB  - Pregnant rhesus macaques were treated with 0.5 or 2.5 mg/kg triamcinolone 
      acetonide (TAC) or 1.0 or 10.0 mg/kg dexamethasone sodium phosphate (DEX) between 
      20 and 50 gestational days (GD). Treatment with TAC at 2.5 mg/kg resulted in a 
      fetal loss of 71%; 3/5 recovered fetuses displayed an encephalocele or 
      meningocele. All other treatment groups displayed minor cranial skeletal 
      abnormalities consistent with glucocorticoid-mediated teratogenesis. DEX was 
      shown to have a lower teratogenic potential than TAC in this species.
FAU - Jerome, C P
AU  - Jerome CP
AD  - Department of Comparative Medicine, Bowman Gray School of Medicine, Wake Forest 
      University, Winston Salem, NC.
FAU - Hendrickx, A G
AU  - Hendrickx AG
LA  - eng
GR  - RR00169/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - J Med Primatol
JT  - Journal of medical primatology
JID - 0320626
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Abnormalities, Drug-Induced/pathology/*veterinary
MH  - Animals
MH  - Body Weight
MH  - Brain/pathology
MH  - Cephalometry
MH  - Dexamethasone/*adverse effects
MH  - Encephalocele/chemically induced
MH  - Female
MH  - *Macaca
MH  - *Macaca mulatta
MH  - Meningocele/chemically induced
MH  - Monkey Diseases/*pathology
MH  - Organ Size
MH  - Pregnancy
MH  - Pregnancy Outcome/veterinary
MH  - Skull/abnormalities
MH  - Triamcinolone Acetonide/*adverse effects
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - J Med Primatol. 1988;17(4):195-203.