PMID- 31935516
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220531
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 64
DP  - 2020 Jun
TI  - Endogenous TAP-independent MHC-I antigen presentation: not just the ER lumen.
PG  - 9-14
LID - S0952-7915(19)30100-1 [pii]
LID - 10.1016/j.coi.2019.12.003 [doi]
AB  - Altered and infected cells are eliminated by CD8(+) cytotoxic T lymphocytes. This 
      requires production of antigenic peptides mostly in the cytosol, transport to the 
      endoplasmic reticulum (ER) by the transporter associated with antigen processing 
      (TAP), and cell surface presentation by major histocompatibility complex class I 
      (MHC-I). Strikingly, antigen presentation occurs without TAP, although it is 
      inefficient and associated to human pathology. TAP-independent peptides derive 
      both from membrane and secreted proteins, as well as cytosolic ones. The 
      efficiency of TAP-independent presentation may be impacted by the availability of 
      receptive MHC-I, and in turn by the functional presence in the ER of the 
      peptide-loading complex, itself anchored on TAP. Without TAP, surface expression 
      of human leukocyte antigen (HLA)-B allotypes varies widely, with those presenting 
      a broader peptide repertoire among the most TAP-independent. Much remains to be 
      learned on the alternative cellular pathways for antigen presentation in the 
      absence of TAP.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Del Val, Margarita
AU  - Del Val M
AD  - Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Nicolas Cabrera 1, 28049 
      Madrid, Spain. Electronic address: mdval@cbm.csic.es.
FAU - Anton, Luis C
AU  - Anton LC
AD  - Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Nicolas Cabrera 1, 28049 
      Madrid, Spain.
FAU - Ramos, Manuel
AU  - Ramos M
AD  - Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Nicolas Cabrera 1, 28049 
      Madrid, Spain.
FAU - Munoz-Abad, Victor
AU  - Munoz-Abad V
AD  - Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Nicolas Cabrera 1, 28049 
      Madrid, Spain.
FAU - Campos-Sanchez, Elena
AU  - Campos-Sanchez E
AD  - Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Nicolas Cabrera 1, 28049 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200111
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - *ATP-Binding Cassette Transporters/metabolism
MH  - *Antigen Presentation
MH  - CD8-Positive T-Lymphocytes
MH  - *Endoplasmic Reticulum/metabolism
MH  - HLA Antigens/metabolism
MH  - *Histocompatibility Antigens Class I/metabolism
MH  - Humans
EDAT- 2020/01/15 06:00
MHDA- 2022/04/05 06:00
CRDT- 2020/01/15 06:00
PHST- 2019/11/04 00:00 [received]
PHST- 2019/12/11 00:00 [accepted]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2020/01/15 06:00 [entrez]
AID - S0952-7915(19)30100-1 [pii]
AID - 10.1016/j.coi.2019.12.003 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2020 Jun;64:9-14. doi: 10.1016/j.coi.2019.12.003. Epub 2020 
      Jan 11.