PMID- 31935575
OWN - NLM
STAT- MEDLINE
DCOM- 20200422
LR  - 20200422
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 247
DP  - 2020 May
TI  - Effects of PM(2.5) exposure during gestation on maternal gut microbiota and 
      pregnancy outcomes.
PG  - 125879
LID - S0045-6535(20)30071-0 [pii]
LID - 10.1016/j.chemosphere.2020.125879 [doi]
AB  - A number of studies have reported that fine particulate matter (PM(2.5)) exposure 
      is associated with adverse pregnancy outcomes. Moreover, PM(2.5) exposure 
      contributes to changes of gut microbiota. However, influences of PM(2.5) exposure 
      during gestation on maternal gut microbiota and pregnancy outcomes were not well 
      understood. Here we performed a study using mice models. Dams were exposed to 
      PM(2.5) suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 
      12 and 15. Pregnancy outcomes, maternal gut microbiota and short chain fatty 
      acids on GD 18 were all measured. The fetal body weight of PM(2.5) group was 
      significantly lower than that of control group (p < 0.05). Meanwhile, the fetal 
      body length of PM(2.5) group was significantly shorter than that of control group 
      (p < 0.05). The Shannon or Simpson index of PM(2.5) group were higher than that 
      of control group (p < 0.05). At the phyla level, compared to dams in control 
      group, mice in the PM(2.5) group had higher ratio of phyla Proteobacteria, 
      Candidatus Saccharibacteria and Fusobacteria and lower ratio of phyla 
      Acidobacteria, Gemmatimonadetes and Deferribacteres in the gut. Compared with 
      control group, the concentration of isobutyric acid was higher in PM(2.5) group, 
      but butyric acid concentration was lower in PM(2.5) group (p < 0.05). These 
      findings suggested that prenatal exposure to PM(2.5) had an effect on birth 
      weight of fetus. Meanwhile, PM(2.5) tracheal exposure during gestation caused 
      changes in the distribution and structure of gut microbiota of dams.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Zhou, Yalin
AU  - Zhou Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Yong Li
AU  - Yong Li
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Qin, Yong
AU  - Qin Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Yu, Lanlan
AU  - Yu L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Li, Ruijun
AU  - Li R
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Chen, Yuhan
AU  - Chen Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China.
FAU - Xu, Yajun
AU  - Xu Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, 100083, China; Beijing Key Laboratory of Toxicological 
      Research and Risk Assessment for Food Safety, Peking University, Beijing, 100083, 
      China. Electronic address: xuyajun@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200109
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Air Pollutants/adverse effects/*toxicity
MH  - Animals
MH  - Birth Weight
MH  - Female
MH  - Fetus/chemistry
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Humans
MH  - Maternal Exposure/adverse effects/*statistics & numerical data
MH  - Mice
MH  - Particulate Matter/analysis/*toxicity
MH  - Pregnancy
MH  - *Pregnancy Outcome
OTO - NOTNLM
OT  - Gut microbiota
OT  - PM(2.5)
OT  - Pregnancy outcomes
OT  - Short chain fatty acids
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2020/01/15 06:00
MHDA- 2020/04/23 06:00
CRDT- 2020/01/15 06:00
PHST- 2019/11/06 00:00 [received]
PHST- 2020/01/06 00:00 [revised]
PHST- 2020/01/08 00:00 [accepted]
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2020/04/23 06:00 [medline]
PHST- 2020/01/15 06:00 [entrez]
AID - S0045-6535(20)30071-0 [pii]
AID - 10.1016/j.chemosphere.2020.125879 [doi]
PST - ppublish
SO  - Chemosphere. 2020 May;247:125879. doi: 10.1016/j.chemosphere.2020.125879. Epub 
      2020 Jan 9.