PMID- 31935763
OWN - NLM
STAT- MEDLINE
DCOM- 20210604
LR  - 20210604
IS  - 1439-1899 (Electronic)
IS  - 0174-304X (Linking)
VI  - 51
IP  - 4
DP  - 2020 Aug
TI  - Acute Disseminated Encephalomyelitis followed by Optic Neuritis: A Rare Syndrome 
      of Uncertain Treatment and Prognosis.
PG  - 286-291
LID - 10.1055/s-0039-3402004 [doi]
AB  - AIM: Acute Disseminated Encephalomyelitis followed by optic neuritis (ADEM-ON), 
      first described in 2013, is a rare demyelinating syndrome, typical of the 
      pediatric age. We conducted a mini review of the existing literature, focusing on 
      clinical, laboratory, radiological, therapeutic, and prognostic aspects in order 
      to improve the identification of new cases. METHODS: We searched PubMed and 
      Cochrane Library for studies on ADEM-ON between 2013 and 2018. RESULTS 
      EXAMINATION: of the reported cases (three case reports and eight observational 
      studies) established the following features. Time between ADEM and ON is highly 
      variable. Almost all patients show antimyelin oligodendrocyte glycoprotein 
      antibody (MOG-abs) seropositivity. High-dose intravenous steroid and 
      plasmapheresis efficacy is reported for the acute phase; oral prednisone and 
      other maintenance drugs may be useful in avoiding relapses. The clinical history 
      may lead to a complete recovery but also to residual deficits. CONCLUSION: 
      MOG-abs detection strongly supports ADEM-ON diagnosis, confirming this entity as 
      part of MOG-abs spectrum disorder. Owing to the very small number of cases so far 
      reported, predicting clinical evolution is very difficult.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Serra, Maria
AU  - Serra M
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
FAU - Presicci, Anna
AU  - Presicci A
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
FAU - Fucci, Martina
AU  - Fucci M
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
FAU - Margari, Mariella
AU  - Margari M
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
FAU - Palumbi, Roberto
AU  - Palumbi R
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
FAU - Peschechera, Antonia
AU  - Peschechera A
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
FAU - Margari, Lucia
AU  - Margari L
AUID- ORCID: 0000-0002-9203-3373
AD  - Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, 
      Universita degli Studi di Bari "Aldo Moro," Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200114
PL  - Germany
TA  - Neuropediatrics
JT  - Neuropediatrics
JID - 8101187
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - *Encephalomyelitis, Acute Disseminated/diagnosis/immunology/therapy
MH  - Humans
MH  - Myelin-Oligodendrocyte Glycoprotein/*immunology
MH  - *Optic Neuritis/diagnosis/immunology/therapy
MH  - Prognosis
MH  - Syndrome
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/01/15 06:00
MHDA- 2021/06/05 06:00
CRDT- 2020/01/15 06:00
PHST- 2020/01/15 06:00 [pubmed]
PHST- 2021/06/05 06:00 [medline]
PHST- 2020/01/15 06:00 [entrez]
AID - 10.1055/s-0039-3402004 [doi]
PST - ppublish
SO  - Neuropediatrics. 2020 Aug;51(4):286-291. doi: 10.1055/s-0039-3402004. Epub 2020 
      Jan 14.