PMID- 31938130
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200119
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 11
IP  - 1
DP  - 2018
TI  - A case study of t(14;22)(q32;q11) involving immunoglobulin heavy and light chain 
      in follicular lymphoma.
PG  - 448-454
AB  - Chromosome 14 is the most frequently rearranged chromosome in non-Hodgkin 
      lymphoma (NHL), with aberrations particularly involving the heavy-chain 
      immunoglobulin gene (IGH) in the chromosome band 14q32. Several translocation 
      partners have been described: t(14;18)(q32;21)/IGH-BCL2 in follicular lymphoma 
      (FL), t(11;14)(q13;q32)/CCND1-IGH in mantle cell lymphoma, and 
      t(8;14)(q24;q32)/MYC-IGH in Burkitt lymphoma. The chromosomal locus 22q11 
      contains two important genes associated with leukemia and lymphoma; one is BCR, 
      which fuses with ABL from 9q34 in chronic myeloid leukemia, and the other is the 
      immunoglobulin lambda gene (IGL), which is rarely involved in the translocations 
      observed in B-cell NHL. The t(14;22)(q32;q11) translocation has been previously 
      reported in 8 cases of B-cell NHL; however, the translocation between IGH and IGL 
      has been experimentally confirmed using fluorescence in situ hybridization (FISH) 
      for only 4 cases. Here, we describe the first case of FL with a 
      t(14;22)(q32;q11)/IGH-IGL translocation confirmed using FISH analysis. The 
      patient in our case report was immunocompromised and was treated for aplastic 
      anemia with cyclosporine A (CsA). The patient was diagnosed with follicular 
      lymphoma, most likely caused by CsA.
CI  - IJCEP Copyright (c) 2018.
FAU - Abe, Shori
AU  - Abe S
AD  - Department of Hematology, Tohoku Medical and Pharmaceutical University 
      Wakabayashi Hospital Sendai, Japan.
AD  - Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical 
      University Japan.
FAU - Katsushima, Hiroki
AU  - Katsushima H
AD  - Division of Hematopathology, Tohoku University Hospital Japan.
FAU - Fujishima, Fumiyoshi
AU  - Fujishima F
AD  - Department of Anatomic Pathology, School of Medicine, Tohoku University Graduate 
      Japan.
FAU - Nomura, Jun
AU  - Nomura J
AD  - Department of Hematology, Tohoku Medical and Pharmaceutical University 
      Wakabayashi Hospital Sendai, Japan.
FAU - Kameoka, Junichi
AU  - Kameoka J
AD  - Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical 
      University Japan.
FAU - Ichinohasama, Ryo
AU  - Ichinohasama R
AD  - Division of Hematopathology, Tohoku University Hospital Japan.
LA  - eng
PT  - Case Reports
DEP - 20180101
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6957971
OTO - NOTNLM
OT  - Follicular lymphoma
OT  - aplastic anemia
OT  - cyclosporine A
OT  - translocation t(14;22)(q32;q11)
COIS- None.
EDAT- 2018/01/01 00:00
MHDA- 2018/01/01 00:01
PMCR- 2018/01/01
CRDT- 2020/01/16 06:00
PHST- 2017/03/15 00:00 [received]
PHST- 2017/06/05 00:00 [accepted]
PHST- 2020/01/16 06:00 [entrez]
PHST- 2018/01/01 00:00 [pubmed]
PHST- 2018/01/01 00:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2018 Jan 1;11(1):448-454. eCollection 2018.