PMID- 31938161
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200119
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 11
IP  - 2
DP  - 2018
TI  - Association of HLA-DRB1/DQB1 polymorphism with high-risk HPV infection and 
      cervical intraepithelial neoplasia women from Shanghai.
PG  - 748-756
AB  - Persistent human papillomavirus (HPV) infection is the main causative agent for 
      cervical intraepithelial neoplasia (CIN) and cancer. Variability in host 
      immunogenetic factors is important in determining the overall cellular immune 
      response to the HPV infection. This study was carried out to confirm the 
      association of human leukocyte antigen (HLA) class II DRB1 and DQB1 alleles with 
      CIN and HPV persistent infections in women from Shanghai in a case-controlled 
      study. A total of 170 patients, including 105 HPV positive patients and 65 HPV 
      negative women (control) participated in the study. HybriBio's proprietary 
      flow-through hybridization technique was used to perform HPV genotyping. 
      Low-resolution PCR-sequence specific priming (PCR-SSP) was used to genotype HLA 
      class II for DRB1 and DQB1 loci. Binary and multivariate logistic regression 
      analysis highlighted the association of specific alleles with CIN and HPV 
      persistent infections after adjusting for the confounding factor of age. 
      HLA-DQB1*02 and *06 is significantly associated with increased risk of HPV16 
      persistent infection (P (c) < 0.013). HLA-DRB1*09 is significantly associated 
      with increased risk for CIN, whereas the -DRB1*16 exhibit protective to CIN (P < 
      0.05). Significant association is found for HLA-DQB1*04 and *06 with increased 
      risk for CIN (P < 0.05). There were possible associations of specific HLA class 
      II alleles either with risk of persistent HPV infection or with developing CIN.
CI  - IJCEP Copyright (c) 2018.
FAU - Zhao, Junwei
AU  - Zhao J
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
FAU - Lin, Hui
AU  - Lin H
AD  - School of Medicine, Tongji University Shanghai 200092, China.
FAU - Yu, Wen
AU  - Yu W
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
FAU - Xu, Xianghong
AU  - Xu X
AD  - Clinical and Translational Research Center, Shanghai First Maternity and Infant 
      Hospital, School of Medicine, Tongji University Shanghai 201240, China.
FAU - Hu, Huiyan
AU  - Hu H
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
FAU - Zhu, Laifang
AU  - Zhu L
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
FAU - Han, Lingfei
AU  - Han L
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
FAU - Li, Fang
AU  - Li F
AD  - Department of Gynaecology, Shanghai First Maternity and Infant Hospital, School 
      of Medicine, Tongji University Shanghai 201240, China.
LA  - eng
PT  - Journal Article
DEP - 20180201
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6958010
OTO - NOTNLM
OT  - HLA-DRB1/DQB1
OT  - cervical intraepithelial neoplasia
OT  - persistent human papillomavirus infection
OT  - polymorphism
COIS- None.
EDAT- 2018/02/01 00:00
MHDA- 2018/02/01 00:01
PMCR- 2018/02/01
CRDT- 2020/01/16 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/09/28 00:00 [accepted]
PHST- 2020/01/16 06:00 [entrez]
PHST- 2018/02/01 00:00 [pubmed]
PHST- 2018/02/01 00:01 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2018 Feb 1;11(2):748-756. eCollection 2018.