PMID- 31938209
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200325
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 11
IP  - 3
DP  - 2018
TI  - Bioinformatic analysis of differential expression and core GENEs in breast 
      cancer.
PG  - 1146-1156
AB  - Breast cancer (BRCA) is one of the most common malignancies in women. The gene 
      expression profile of GSE103512 from the GEO database was downloaded in order to 
      find key genes involved in the occurrence and development of BRCA. 75 samples, 
      including 65 cancer and 10 normal samples, were included in this analysis. 
      Differentially expressed genes (DEGs) between BRCA patients and health people 
      were chosen using R tool. We next performed gene ontology (GO) analysis and Kyoto 
      Encyclopedia of Gene and Genome (KEGG) pathway analysis using the Database for 
      Annotation, Visualization and Integrated Discovery (DAVID). Moreover, Cytoscape 
      with Search Tool for the Retrieval of Interacting Genes (STRING) was utilized to 
      visualize protein-protein interaction (PPI) of these DEGs. The related genes and 
      medicines specific to hub genes were predicted by CBioportal. We screened a total 
      of 357 DEGs including 77 up-regulated and 280 down-regulated. A series of BRCA 
      related GO terms and pathways were identified by analysis of these DEGs. 
      Insulin-like growth factor 1 (IGF1); epidermal growth factor receptor (EGFR); 
      v-jun avian sarcoma virus 17 oncogene homolog (JUN) and Estrogen Receptor 1 
      (ESR1) of the DEGs were screened by construction of the PPI network and the 
      degree of connectivity. IGF1 and ESR1 were finally selected as potential hub 
      genes and treatment targets of BRCA. In conclusion, this bioinformatics analysis 
      demonstrated that DEGs and hub genes, such as IGF1, might regulate the 
      development of gastric cancer. These DEGs could be used as new biomarkers for 
      diagnosis and to guide the combination medicine of BRCA.
CI  - IJCEP Copyright (c) 2018.
FAU - Dong, Hongchang
AU  - Dong H
AD  - The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of 
      Biochemistry, Shihezi University School of Medicine Shihezi, Xinjiang, China.
FAU - Zhang, Shuai
AU  - Zhang S
AD  - The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of 
      Biochemistry, Shihezi University School of Medicine Shihezi, Xinjiang, China.
FAU - Wei, Yu
AU  - Wei Y
AD  - The First Affiliated Hospital of Medical College of Shihezi University Shihezi, 
      Xinjiang, China.
FAU - Liu, Chunyan
AU  - Liu C
AD  - The First Affiliated Hospital of Medical College of Shihezi University Shihezi, 
      Xinjiang, China.
FAU - Wang, Na
AU  - Wang N
AD  - The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of 
      Biochemistry, Shihezi University School of Medicine Shihezi, Xinjiang, China.
FAU - Zhang, Pan
AU  - Zhang P
AD  - The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of 
      Biochemistry, Shihezi University School of Medicine Shihezi, Xinjiang, China.
FAU - Zhu, Jingling
AU  - Zhu J
AD  - The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of 
      Biochemistry, Shihezi University School of Medicine Shihezi, Xinjiang, China.
FAU - Huang, Jin
AU  - Huang J
AD  - The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of 
      Biochemistry, Shihezi University School of Medicine Shihezi, Xinjiang, China.
LA  - eng
PT  - Journal Article
DEP - 20180301
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6958129
OTO - NOTNLM
OT  - Breast cancer
OT  - bioinformatics analysis
OT  - biomarker
OT  - differential expression genes
OT  - therapeutic
COIS- None.
EDAT- 2018/03/01 00:00
MHDA- 2018/03/01 00:01
PMCR- 2018/03/01
CRDT- 2020/01/16 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2017/12/22 00:00 [accepted]
PHST- 2020/01/16 06:00 [entrez]
PHST- 2018/03/01 00:00 [pubmed]
PHST- 2018/03/01 00:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2018 Mar 1;11(3):1146-1156. eCollection 2018.