PMID- 31938263
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200119
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 11
IP  - 3
DP  - 2018
TI  - Sequence variation in microRNA-34a is associated with diabetes mellitus 
      susceptibility in a southwest Chinese Han population.
PG  - 1637-1644
AB  - Type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) seriously impact 
      the prognosis and survival of patients. Abundant studies suggest that single 
      nucleotide polymorphisms (SNPs) within regulatory regions of miRNAs modulate 
      progression of various diseases including DM and DN. However, evidence for 
      exploring the mechanism in DM and DN are still insufficient. This study was 
      performed to discuss the association of SNPs in the regulatory region of 
      hsa-miR-34a with DM or DN susceptibility in the southwest Chinese Han population. 
      Three SNPs (rs12128240, rs2666433, rs6577555) in miR-34a were analyzed in the 
      T2DM patients with or without DN and normal controls. RT-qPCR was performed to 
      measure expression of miR-34a. Real-time PCR was used for amplification of SNPs. 
      MiR-34a was over-expressed in T2DM and DM patients. Both the distribution of GG 
      genotypes and the G allele frequency of rs2666433 were significantly different 
      between the T2DM and control groups (P=0.009, P=0.008 respectively). Univariate 
      analysis with additive and recessive models for rs2666433 polymorphisms showed an 
      association with DM (P=0.023; P=0.009 respectively), and a stronger association 
      was found in an additive model (P=0.001) when compared with DN. After adjustment 
      for clinical covariates, the GG genotype was still significantly different for 
      the recessive model (OR 2.297; CI 1.031-5.121; P=0.042) in T2DM by multivariate 
      analysis. In conclusion, our study demonstrates that a potential variant 
      rs2666433 in the miR-34a regulatory region may significantly associate with the 
      occurrence of T2DM.
CI  - IJCEP Copyright (c) 2018.
FAU - Sun, Yan
AU  - Sun Y
AD  - Molecular Medicine and Cancer Research Center, Chongqing Medical University 
      Chongqing 400016, China.
FAU - Peng, Rui
AU  - Peng R
AD  - Department of Bioinformatics, Chongqing Medical University Chongqing, China.
FAU - Li, Ailing
AU  - Li A
AD  - Molecular Medicine and Cancer Research Center, Chongqing Medical University 
      Chongqing 400016, China.
AD  - The People's Hospital of Rongchang District Chongqing, China.
FAU - Zhang, Luyu
AU  - Zhang L
AD  - Molecular Medicine and Cancer Research Center, Chongqing Medical University 
      Chongqing 400016, China.
FAU - Liu, Handeng
AU  - Liu H
AD  - Molecular Medicine and Cancer Research Center, Chongqing Medical University 
      Chongqing 400016, China.
FAU - Peng, Huiming
AU  - Peng H
AD  - Molecular Medicine and Cancer Research Center, Chongqing Medical University 
      Chongqing 400016, China.
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - Molecular Medicine and Cancer Research Center, Chongqing Medical University 
      Chongqing 400016, China.
LA  - eng
PT  - Journal Article
DEP - 20180301
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6958157
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - polymorphism
OT  - type 2 diabetes
COIS- None.
EDAT- 2018/03/01 00:00
MHDA- 2018/03/01 00:01
PMCR- 2018/03/01
CRDT- 2020/01/16 06:00
PHST- 2017/11/22 00:00 [received]
PHST- 2017/12/15 00:00 [accepted]
PHST- 2020/01/16 06:00 [entrez]
PHST- 2018/03/01 00:00 [pubmed]
PHST- 2018/03/01 00:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2018 Mar 1;11(3):1637-1644. eCollection 2018.