PMID- 31938886
OWN - NLM
STAT- MEDLINE
DCOM- 20200820
LR  - 20220601
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 57
IP  - 6
DP  - 2020 Jun
TI  - Evaluating the correlation of the impairment between skeletal muscle and heart 
      using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model.
PG  - 673-679
LID - 10.1007/s00592-019-01460-0 [doi]
AB  - AIMS: To investigate the correlation of impairment in skeletal muscle and heart 
      in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic 
      resonance image (MRI). METHODS: Fifteen T2DM monkeys and fourteen healthy control 
      (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal 
      muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and 
      the function and strain of heart were evaluated by MRI. Three regions of 
      interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and 
      tibialis anterior muscle (TA) for image analysis. RESULTS: Eight T2DM monkeys and 
      eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF 
      reserves were found significantly decreased in T2DM during inflation in SOL, GAS 
      and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia 
      in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak 
      longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate 
      (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal 
      PDSR) were seen significantly different in T2DM compared to HC monkeys (all 
      p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF 
      reserves in SOL, GAS and TA during inflation in all monkeys. CONCLUSIONS: The 
      impaired microcirculation of skeletal muscle and the myocardial deformation were 
      found in T2DM monkeys with normal ejection fraction. And a negative correlation 
      was existed in the longitudinal PSSR and the SMBF reserves.
FAU - Chen, Yushu
AU  - Chen Y
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Zeng, Wen
AU  - Zeng W
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
AD  - Department of Radiology, First Affiliated Hospital of Kunming Medical University, 
      Kunming, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Zhu, Tong
AU  - Zhu T
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Sun, Jiayu
AU  - Sun J
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Liang, Zhigang
AU  - Liang Z
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Yang, Zunyuan
AU  - Yang Z
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China.
FAU - Wu, Bing
AU  - Wu B
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Song, Bin
AU  - Song B
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China.
FAU - Wang, Fangtong
AU  - Wang F
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China.
FAU - Liang, Yinan
AU  - Liang Y
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China.
FAU - Gong, Li
AU  - Gong L
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Mallinckrodt Institute of Radiology, Washington University School of Medicine, 
      St. Louis, MO, USA.
FAU - Gao, Fabao
AU  - Gao F
AUID- ORCID: 0000-0003-2257-3275
AD  - Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, 
      Chengdu, 610041, Sichuan, China. gaofabao@wchscu.cn.
AD  - Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China. gaofabao@wchscu.cn.
LA  - eng
GR  - 81520108014/National Natural Science Foundation of China/
GR  - 81771800/National Natural Science Foundation of China/
GR  - 81829003/National Natural Science Foundation of China/
GR  - 2016YFA0201402/State's Key Project of Research and Development Plan of China/
PT  - Journal Article
DEP - 20200114
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Animals
MH  - Coronary Vessels/diagnostic imaging/pathology
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/pathology/physiopathology
MH  - Diabetic Angiopathies/diagnosis/pathology/physiopathology
MH  - *Disease Models, Animal
MH  - Female
MH  - Heart/*diagnostic imaging/physiopathology
MH  - Humans
MH  - *Macaca mulatta
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Microcirculation/physiology
MH  - Muscle, Skeletal/blood supply/*diagnostic imaging/pathology/physiopathology
MH  - Myocardium/pathology
MH  - Regional Blood Flow
OTO - NOTNLM
OT  - Diabetes
OT  - Impairment
OT  - MRI
OT  - Microcirculation
OT  - Monkey
EDAT- 2020/01/16 06:00
MHDA- 2020/08/21 06:00
CRDT- 2020/01/16 06:00
PHST- 2019/09/27 00:00 [received]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2020/01/16 06:00 [pubmed]
PHST- 2020/08/21 06:00 [medline]
PHST- 2020/01/16 06:00 [entrez]
AID - 10.1007/s00592-019-01460-0 [pii]
AID - 10.1007/s00592-019-01460-0 [doi]
PST - ppublish
SO  - Acta Diabetol. 2020 Jun;57(6):673-679. doi: 10.1007/s00592-019-01460-0. Epub 2020 
      Jan 14.